What Is R-Clostridium Histolyticum Collagenase H?
R-Clostridium Histolyticum Collagenase H, often shortened to ColH, is an enzyme sourced from a carefully selected strain of the naturally occurring bacterium Clostridium histolyticum. Enzymes in the collagenase family are specialists at cutting the long protein chains that make up collagen. In skincare this controlled action can help renew the surface of the skin without the harshness of physical scrubs.
The cosmetic world first took note of collagenase decades ago when medical researchers used it to clean wounds. Advancements in biotechnology have since allowed manufacturers to ferment non-pathogenic, lab-grown cultures of C. histolyticum under strict conditions, then isolate and purify Collagenase H for topical use. Modern processing steps include microfiltration, chromatography and gentle drying to keep the enzyme active while removing bacterial remnants, creating a high-purity ingredient that meets cosmetic safety standards.
Because of its precision and mildness ColH is now found in a range of formulas aimed at refining texture and boosting skin radiance. You might spot it in rinse-off exfoliating masks, anti-aging serums, brightening ampoules, post-peel soothing gels, body firming lotions and even speciality hand or neck creams that target crepey skin.
R-Clostridium Histolyticum Collagenase H’s Cosmetic Benefits/Uses
In cosmetics ColH plays one main role:
Skin conditioning. By gently loosening built-up or damaged collagen fragments on the surface, the enzyme helps smooth rough patches, soften fine lines and create a fresher looking complexion. This mild bio-exfoliation also clears the way for moisturizers and antioxidants to sink in more effectively, so the rest of your routine can work better.
Who Can Use R-Clostridium Histolyticum Collagenase H
ColH is generally suitable for all main skin types including normal, dry, combination and oily. Its gentle enzyme action makes it an option for many people with sensitive skin as well, although very reactive or compromised skin should introduce it slowly to be safe.
The enzyme is produced through a controlled fermentation process that does not rely on animal tissues, so it is considered appropriate for both vegans and vegetarians. Finished products can vary though, so those following a strict plant based lifestyle may still wish to check the full ingredient list for animal derived additives such as beeswax or lactose.
Pregnant and breastfeeding women usually tolerate topical ColH when it appears in low cosmetic concentrations. Because every pregnancy is unique and research in this specific group is limited, this information is not medical advice. Expectant or nursing mothers should take any new skincare routine to their healthcare provider for a quick review.
ColH does not make skin more prone to sunburn and is not known to trigger photosensitivity. Daily sunscreen is still a smart habit, especially when using any form of exfoliation that can reveal fresher skin.
The enzyme plays well with most common actives including niacinamide and hyaluronic acid. If you use strong chemical peels or retinoids in the same routine, apply them at different times of day to avoid stacking too much exfoliation at once.
Potential Side Effects/Adverse Reactions
Responses to topical R-Clostridium Histolyticum Collagenase H vary from person to person. The effects listed below are possibilities rather than expectations and most people will not experience them when the ingredient is used at the correct cosmetic level.
- Temporary redness or warmth right after application
- Mild stinging or tingling that fades within minutes
- Dryness or flakiness if the formula is used too often
- Allergic contact dermatitis in those sensitive to the enzyme or preservatives in the product
- Heightened sensitivity when layered with other potent exfoliants or retinoids
If you notice persistent discomfort swelling or a rash stop using the product and consult a medical professional for guidance.
Comedogenic Rating
Rating: 0 / 5
R-Clostridium Histolyticum Collagenase H is a water-soluble enzyme with no oily or waxy residues so it does not clog pores. It works on protein bonds, not sebum, which is why the likelihood of it backing up follicles is virtually nil.
This makes ColH a comfortable choice for people prone to acne or breakouts.
Keep in mind that the final product formula matters: heavy butters, silicones or occlusive thickeners paired with the enzyme could still trigger congestion even though the enzyme itself is non-comedogenic.
Summary
R-Clostridium Histolyticum Collagenase H is a precision bio-exfoliant that conditions skin by snipping away surface-level collagen fragments. This gentle enzymatic action smooths texture, softens fine lines and improves the absorption of follow-up skincare.
Although its medical roots have been known for years, ColH is still a niche addition in mainstream cosmetics so you will usually find it in targeted serums masks or professional-style treatments rather than every drugstore cream.
Safety data show low irritation risk when used at cosmetic levels, giving it a favorable profile for most skin types including sensitive and acne-prone. As with any new active it is smart to patch test a product before full-face use to make sure your skin agrees with the full formula.