Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
Share:
Inside this article:

We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media?

Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media is the nutrient rich liquid that has spent several days bathing lab grown cells reprogrammed from the red junglefowl, the wild ancestor of the domestic chicken. While the cells stay behind for further research, the leftover medium is harvested because it now holds a cocktail of proteins, peptides, sugars, amino acids and natural moisturizers released by the cells during growth. First explored in regenerative biology, the ingredient caught the attention of skincare formulators looking for new ways to boost skin hydration. To make it, scientists take a small, ethically sourced sample of red junglefowl tissue, convert the cells to a pluripotent state, then culture them under strict sterile conditions. After a set growth period, the spent medium is removed, carefully filtered to eliminate cellular debris, and preserved for cosmetic use. You will usually find this ingredient in hydrating serums, sheet masks, anti aging creams, essence lotions and targeted moisture booster treatments.

Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media’s Cosmetic Benefits/Uses

In skincare formulas this ingredient plays one primary role.

As a humectant it attracts water from the environment and the deeper layers of skin, binding it to the surface. This surge of moisture helps the complexion feel softer, look plumper and appear smoother while supporting a healthy skin barrier and improving the spreadability of the overall product.

Who Can Use Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media

Generous humectants tend to work for most skin types so this ingredient is generally suitable for dry, normal and combination skin looking for extra hydration. Oily or acne prone complexions can also benefit because the medium is lightweight and water based, not greasy. Sensitive skin usually tolerates it well since it is free of fragrance and harsh solvents though anyone with a known egg or poultry allergy may want to skip it out of caution.

The ingredient is animal derived because the starting cells come from red junglefowl tissue. That means it does not meet strict vegan or vegetarian standards even though no birds are harmed during manufacturing. Consumers following plant only routines will want to choose another humectant option.

Current data shows no specific risks for women who are pregnant or breastfeeding when this material is used topically in cosmetics. Still individual circumstances vary so this content is not medical advice. Expectant or nursing mothers should show the full ingredient list to their healthcare provider before adding new products just to stay on the safe side.

Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media does not increase sun sensitivity and can be worn morning or night without boosting the need for extra sunscreen. It also layers well with common actives like vitamin C, niacinamide and retinol.

Potential Side Effects/Adverse Reactions

Responses to topical Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media vary from one person to another. The points below outline possible side effects but they are unlikely for most users when the ingredient is properly formulated.

  • Mild redness or irritation
  • Itchiness or a tight feeling on very reactive skin
  • Rare allergic reaction in people sensitive to poultry proteins
  • Breakouts if combined with comedogenic ingredients in the same formula

Stop use and consult a qualified healthcare professional if you notice any persistent discomfort or signs of an allergic reaction.

Comedogenic Rating

Rating: 0 / 5

This ingredient is water based and packed with lightweight hydrators that sit on the surface rather than clogging pores so it earns the lowest possible score. No heavy oils or waxes are present and its molecules are mostly small enough to rinse away easily. That makes it a good option for people who deal with blackheads or breakouts because it is very unlikely to trigger congestion.

Extra note: the finished product’s full formula matters. If the brand pairs this media with thick butters or high-level silicones the overall product could still end up pore clogging even though the media itself is not.

Summary

Red Junglefowl Induced Pluripotent Cell Culture Conditioned Media is a lab grown humectant that draws water to the skin then locks it in for a plump smooth feel. It works by supplying a mix of naturally secreted proteins sugars and amino acids that bind moisture and support the barrier.

Right now it is still a niche ingredient found mostly in cutting edge K-beauty style serums and masks rather than on every drugstore shelf but interest is growing as brands look for novel animal derived hydrators.

Topically it is considered low risk with minimal irritation potential for most skin types. As with any new skincare ingredient it is smart to patch test before full use so you can be sure your skin stays happy.

Was this article helpful?
More from Glooshi:
ADVERTISEMENT
Get all our top headlines in beauty.
Delivered right to your inbox each week. Zero spam, all goodness, opt-out at anytime.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Get the latest beauty news, top product recommendations & brand-exclusive discount codes direct to your inbox.
Send good feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Send bad feedback:

All feedback is greatly appreciated, anonymous, and will be used to improve the quality of our articles.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Search