What Is Rh-Polypeptide-28?
Rh-Polypeptide-28 is a lab crafted version of a human protein originally linked to the antioxidant enzyme Superoxide Dismutase 1. Scientists take the exact gene that tells our cells how to make this protein and place it into harmless E. coli bacteria. The bacteria work like tiny factories, fermenting and producing the peptide in large amounts. After harvesting, the peptide is purified so it contains only the 20 standard amino acids arranged in the same order found in the human body. It can include up to 154 amino acids, sometimes joined by disulfide bonds or carrying small sugar groups that help stabilize the chain.
The use of recombinant peptides in skincare began in the 1990s when brands looked for safer, more consistent ways to add human-like proteins to creams and serums. By making Rh-Polypeptide-28 in a controlled setting, companies avoid animal sources and batch-to-batch changes. Today you will spot this ingredient in anti-aging serums, recovery masks, intensive moisturizers, eye creams and targeted treatment ampoules where its soothing and conditioning traits are most valuable.
Rh-Polypeptide-28’s Cosmetic Benefits/Uses
When added to a formula Rh-Polypeptide-28 supports skin appearance and product performance in two main ways:
- Reducing agent – Helps neutralize free radicals created by pollution and UV light, which in turn can calm visible redness and delay early signs of aging
- Skin conditioning – Binds water to the surface, leaves skin feeling smoother and can improve softness over time
Who Can Use Rh-Polypeptide-28
Rh-Polypeptide-28 is considered gentle enough for most skin types including dry, normal, combination and oily. Its water-binding and soothing nature makes it especially appealing to sensitive or mature skin, while the lightweight texture it brings to formulas keeps it from feeling heavy on oilier complexions. There are no known mechanisms that would make it unsuitable for darker skin tones or reactive skin beyond the rare chance of individual allergy.
The peptide is generated through fermentation in bacteria, with no animal-derived inputs, so it meets vegan and vegetarian standards.
No specific data links Rh-Polypeptide-28 to risks in pregnancy or breastfeeding. Because hormonal shifts can make skin more reactive it is smart for pregnant or nursing women to review any new skincare with a doctor first. This information is educational only and not medical advice.
Rh-Polypeptide-28 does not increase photosensitivity and can be used in both daytime and nighttime routines. Standard daily sunscreen is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Rh-Polypeptide-28 differ from person to person. The effects listed below are possible yet unlikely when the ingredient is formulated and preserved correctly. Most users will enjoy the benefits without issues.
- Mild redness or warmth shortly after application
- Temporary tingling or stinging on very sensitive skin
- Local itching or dryness if the formula has a high active load
- Rare allergic contact dermatitis presenting as a rash or swelling
- Incompatibility with highly acidic products applied in the same routine leading to irritation
If any of these reactions occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 / 5
Rh-Polypeptide-28 is a water-soluble peptide with no oils, waxes or fatty acids that could clog pores. It sits on the skin surface, does its job then rinses or wears off without blocking follicles.
This makes it a safe choice for people who are prone to acne or breakouts.
Keep in mind the overall formula matters. Heavy creams or occlusive ingredients paired with the peptide could still trigger congestion even though the peptide itself will not.
Summary
Rh-Polypeptide-28 acts as a reducing agent that helps sweep up free radicals and as a skin-conditioning booster that attracts water for a softer feel. By copying part of the natural Superoxide Dismutase 1 enzyme it calms oxidative stress while its amino acid chain binds moisture to the outer layer.
The peptide is not yet mainstream but it is gaining traction in premium serums and eye treatments as brands look for gentler science-based actives.
Overall safety is high with only isolated reports of mild irritation. As with any new skincare product perform a quick patch test before adding it to your routine just to be sure.