What Is Rh-Polypeptide-59?
Rh-Polypeptide-59 is a lab-engineered version of a naturally occurring human protein called platelet derived growth factor beta. Scientists isolate the gene that codes for this protein from human cells, insert it into a harmless strain of E. coli, then let the bacteria “brew” the peptide through fermentation. After harvesting, the peptide is purified so only the intended chain of up to 109 amino acids remains, sometimes linked by disulfide bonds or carrying small sugar groups. This biotechnological approach ensures a consistent supply without relying on animal or human tissue.
The ingredient first drew attention in medical research focused on wound care, where growth factors help guide skin repair. As cosmetic science advanced, formulators saw its potential to nurture the skin’s surface and support a fresh, well-conditioned look. Today Rh-Polypeptide-59 appears in high-performance serums, anti-aging creams, sheet masks, concentrated ampoules and post-procedure soothing gels, typically positioned as a premium booster for skin vitality.
Rh-Polypeptide-59’s Cosmetic Benefits/Uses
When added to skincare, Rh-Polypeptide-59 offers targeted advantages that revolve around keeping the skin in good shape.
- Skin conditioning – helps maintain a smooth, supple feel, supports the look of renewed firmness and reduces the appearance of dull or stressed skin
- Skin protecting – reinforces the skin’s natural barrier so it can better defend itself against dryness, pollution and everyday irritants
Who Can Use Rh-Polypeptide-59
Rh-Polypeptide-59 is generally well tolerated by all skin types including dry, oily, combination and sensitive skin because it is lightweight and water based. People with a known allergy to growth factors or other proteins should steer clear since even tiny amounts could trigger irritation.
The peptide is made in a lab through bacterial fermentation with no animal parts involved. This means it is suitable for vegans and vegetarians.
Pregnant or breastfeeding women can usually use products that feature Rh-Polypeptide-59 since the molecule is large and stays on the surface of the skin. This is not medical advice; anyone who is expecting or nursing should show the product to a doctor first to be safe.
Rh-Polypeptide-59 does not cause photosensitivity so it will not make skin more prone to sunburn. Standard daytime sun protection is still recommended for overall skin health.
The ingredient plays well with most common actives like hyaluronic acid, niacinamide and ceramides although very acidic formulas can lower its stability. Check the product directions for any brand specific guidance.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Rh-Polypeptide-59 vary from person to person. The points below cover potential issues only; when the ingredient is formulated and used correctly most people will not notice any problems.
- Temporary redness or warmth
- Mild itching or tingling during the first few uses
- Allergic contact dermatitis in those sensitive to proteins
- Small breakouts if the finished product contains heavy oils that clog pores
- Stinging on broken or freshly exfoliated skin
If any of these effects occur stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Rh-Polypeptide-59 is a large, water-soluble protein that sits on the surface of the skin and contains no oils or waxes that could block pores, so it does not encourage the formation of comedones. It is therefore suitable for people prone to acne or frequent breakouts. As always, pore clogging risk also depends on the overall formula, so check the other ingredients in the finished product.
Summary
Rh-Polypeptide-59 is mainly used for skin conditioning and skin protecting. By mimicking the naturally occurring platelet derived growth factor beta, it helps support the skin’s renewal signals, keeps moisture levels balanced and reinforces the barrier so skin feels smoother and looks fresher. While not yet a household name, the peptide is gaining traction in high-end serums and post-procedure care because it combines biotech precision with a gentle profile.
Current data shows it is generally safe for all skin types with only rare irritation in protein-sensitive users. Even though reactions are uncommon, it is smart to patch test any new product that contains this peptide before full application.