What Is Rh-Polypeptide-61?
Rh-Polypeptide-61 is the cosmetic name for a lab engineered version of Tripartite Motif-Containing Protein 72, sometimes listed as rh-Polypeptide-29. It belongs to a group of small chains of amino acids known as bioactive peptides that are designed to mimic signals naturally found in human skin. Unlike animal-derived proteins, this ingredient is produced through recombinant DNA technology: scientists insert the genetic code for the peptide into yeast or bacterial cells, those cells are grown in controlled tanks, and the peptide is then purified, filtered and dried into a stable powder for use in formulas. Peptide technology began showing up in skincare in the early 2000s as brands searched for gentler ways to prompt skin renewal; Rh-Polypeptide-61 is one of the newer additions aimed at delivering targeted, skin-friendly results without irritation. You will most often see it listed in concentrated serums, anti-aging creams, eye treatments, sheet masks and post-treatment soothing gels where a silky feel and fast absorption are desired.
Rh-Polypeptide-61’s Cosmetic Benefits/Uses
In topical products Rh-Polypeptide-61 is classified as a skin-conditioning agent, meaning it is added primarily to keep the skin looking and feeling its best. By helping skin hold onto water and supporting a healthy barrier, the peptide leaves the surface smoother, softer and more resilient which translates into improved texture, better bounce and a refreshed appearance in daily use.
Who Can Use Rh-Polypeptide-61
Because it is a lightweight water-binding peptide, Rh-Polypeptide-61 suits nearly all skin types including dry, balanced, combination and oily. Those with sensitive or redness-prone complexions usually tolerate it well since it contains no fragrance or harsh exfoliating elements. Anyone with a known allergy to yeast or bacterial ferment by-products should proceed with caution as the peptide is produced in those microorganisms.
The ingredient is synthetically created without animal input, making it appropriate for vegans and vegetarians. Formulators typically blend it into plant-based or synthetic carriers so no secondary animal derivatives are introduced during production.
Current data shows no specific risks tied to topical use while pregnant or breastfeeding, however this information is limited. This is not medical advice and anyone who is expecting or nursing should review all skincare products with a qualified healthcare professional to stay on the safe side.
Rh-Polypeptide-61 does not make skin more sensitive to sunlight so it is safe for daytime application. Standard daily sunscreen is still recommended for overall skin health. The peptide also layers well with most common actives such as niacinamide, ceramides and hyaluronic acid so it can slot into existing routines without special timing concerns.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Rh-Polypeptide-61 can vary from person to person. The points below outline potential issues that could arise, but they are uncommon when the ingredient is correctly formulated and used as directed.
- Mild redness or warmth short-lived flush that fades after the product absorbs
- Temporary stinging or tingling usually subsides within minutes on freshly cleansed or exfoliated skin
- Itchiness possible in individuals with very reactive skin or existing eczema
- Contact dermatitis rare allergic response that may involve swelling or rash
- Interaction with open cuts or broken barrier can amplify discomfort in areas already compromised
If any irritation persists or worsens stop using the product and consult a medical professional for personalized guidance.
Comedogenic Rating
Rating: 0 (non-comedogenic). Rh-Polypeptide-61 is a small, water-soluble peptide that does not contain heavy oils, waxes or fatty acids that might block pores, so it is very unlikely to contribute to blackheads or breakouts. This makes it suitable for acne-prone or congested skin types. Because the ingredient is usually delivered in light, serum-style bases, its overall formula environment also tends to stay friendly to blemish-prone users. No special considerations regarding pore clogging have been reported in available literature.
Summary
Rh-Polypeptide-61 is a lab-crafted bioactive peptide that conditions skin by attracting water and helping reinforce a healthy barrier, which leaves the surface smoother, softer and more resilient. It is still a niche ingredient but is gaining traction in targeted serums, eye creams and post-procedure treatments for its gentle hydration boost without heaviness.
Current data shows the peptide is low risk for irritation or comedogenicity, so most people can use it with confidence. As with any new skincare addition it is wise to do a quick patch test to confirm personal compatibility before applying it to larger areas of the face.