What Is Rh-Polypeptide-62?
Rh-Polypeptide-62 is a lab engineered peptide that mirrors fragments of hepatocyte growth factor, a molecule the body naturally produces to support repair and renewal. Created through biotechnology, the peptide is fermented in controlled tanks using genetically programmed yeast or bacteria, then purified and dried into a fine powder that blends easily with cosmetic bases. Peptide science took off in skin care during the early 2000s, and Rh-Polypeptide-62 joined the lineup as researchers looked for gentler ways to prompt a fresher, healthier appearance without aggressive actives. Today the ingredient appears in lightweight serums, concentrated ampoules, sheet masks, barrier boosting creams, eye treatments and other anti aging formulas where a silky feel and quick absorption are prized.
Rh-Polypeptide-62’s Cosmetic Benefits/Uses
This peptide offers two key actions that make it attractive to formulators and skin care fans alike:
- Skin conditioning – helps skin feel softer and more supple by supporting natural hydration pathways and smoothing the surface so makeup or sunscreen glides on with less drag
- Skin protecting – reinforces the skin barrier which lowers everyday moisture loss and limits the impact of environmental stress, helping the complexion stay calm and resilient
Who Can Use Rh-Polypeptide-62
Rh-Polypeptide-62 is considered friendly for nearly every skin type including dry, oily, combination and sensitive skin because it focuses on hydration and barrier support without clogging pores or triggering heavy exfoliation. People with very reactive or allergy-prone skin may still want to watch for other ingredients in the overall formula that could cause trouble, but the peptide itself is regarded as gentle.
The peptide is produced entirely through microbial fermentation so it contains no animal-derived material, making it suitable for both vegans and vegetarians.
Current data suggests topical use poses no known risk for women who are pregnant or breastfeeding. That said this is not medical advice and anyone expecting or nursing should clear any new skin care product with a qualified healthcare professional just to be safe.
Rh-Polypeptide-62 does not increase sun sensitivity. Standard daily sunscreen use is still recommended for overall skin health but there is no special photo caution tied to this ingredient.
The peptide is generally compatible with other common actives such as niacinamide, ceramides, hyaluronic acid and non-acidic antioxidants, making it easy to slot into most routines without concern for ingredient clashes.
Potential Side Effects/Adverse Reactions
Individual responses to topical Rh-Polypeptide-62 can vary. The points below outline potential reactions but most people will not notice any problems when the ingredient is formulated and used as intended.
- Mild redness or warmth
- Temporary tingling or stinging at the application site
- Itchiness in very sensitive or compromised skin
- Allergic contact dermatitis in rare cases involving a true peptide allergy or sensitivity to preservation agents in the finished product
- Breakouts if the overall formula contains pore-clogging oils or waxes, though the peptide itself is noncomedogenic
If any irritation or unexpected reaction occurs stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Rh-Polypeptide-62 is a small water-soluble peptide with no oily or waxy residues so it does not obstruct pores or contribute to blackheads. It sits lightly on skin, absorbs quickly and is typically delivered in thin serums or gels that rinse clean during cleansing.
Because of this it is considered safe for acne-prone or breakout-prone skin. The only caveat is the rest of the formula: if the finished product carries rich butters, heavy silicones or thick oils those co-ingredients, not the peptide itself, could raise clogging potential.
Summary
Rh-Polypeptide-62 works mainly as a skin conditioner and protector. By mimicking fragments of the body’s own repair signal it encourages better surface hydration, softens texture and helps reinforce the moisture barrier so skin stays calmer against daily stress.
The ingredient enjoys moderate popularity, showing up most often in mid to high-end serums, ampoules and eye creams where a lightweight silky feel is prized. It is not yet as common as classic hydrators like hyaluronic acid but interest is growing as brands hunt for gentle age-supportive actives.
Safety data so far is reassuring: the peptide is non-comedogenic, vegan friendly and carries a low irritation profile for all skin types including sensitive. As with any new cosmetic it is wise to patch test a product containing Rh-Polypeptide-62 before full use to rule out individual sensitivities.