What Is Rh-Polypeptide-63?
Rh-Polypeptide-63 is a lab-crafted form of superoxide dismutase 2, often shortened to SOD2. This protein-based antioxidant is normally found in human cells where it defends against harmful oxygen molecules. Scientists replicated its structure through biotechnology, using fermentation and controlled protein synthesis to create a stable version suitable for skin care. It first appeared in premium anti-aging lines in the early 2000s when brands began searching for potent yet gentle antioxidants that mimic the body’s own defense system.
After the protein is produced in a sterile bioreactor it goes through filtration, purification and gentle drying to keep its activity intact. The finished powder is then blended into water-based formulas. You will most often see Rh-Polypeptide-63 in serums, moisturizers, sheet masks, eye creams and leave-on treatments aimed at dullness, fine lines and pollution stress.
Rh-Polypeptide-63’s Cosmetic Benefits/Uses
This ingredient serves two key roles in skin care formulas
- Antioxidant: Neutralizes free radicals created by UV light and pollution helping to slow the look of premature aging such as fine lines and uneven tone
- Skin protecting: Supports the skin barrier by reducing oxidative stress which can lessen redness, boost resilience and improve overall skin comfort
Who Can Use Rh-Polypeptide-63
Rh-Polypeptide-63 is gentle enough for all major skin types including dry, oily, combination and sensitive skin because it is non-greasy and free of common irritants like fragrance and dyes. Those with easily inflamed or redness-prone skin may find it especially helpful thanks to its calming antioxidant activity. No particular skin type is advised to avoid it unless there is a known protein allergy.
The ingredient is produced through fermentation in a controlled laboratory setting with no animal-derived materials so it is suitable for both vegans and vegetarians.
Current research has not linked topical Rh-Polypeptide-63 to reproductive concerns. Most dermatologists consider antioxidant peptides low risk during pregnancy and breastfeeding, yet this is not medical advice. Expectant or nursing women should show any skincare routine to their healthcare provider to be safe.
Rh-Polypeptide-63 does not increase photosensitivity. In fact pairing it with daily sunscreen can boost overall protection against environmental stress. It also layers well with vitamins C and E, niacinamide and ceramides without known conflicts.
Potential Side Effects/Adverse Reactions
Responses to topical Rh-Polypeptide-63 differ from person to person. The following list covers potential side effects though most users experience none when the ingredient is formulated and used correctly.
- Mild redness or warming sensation shortly after application
- Temporary itching on very reactive skin
- Rare allergic contact dermatitis in individuals sensitive to peptide proteins or fermentation residues
- Eye irritation if the product accidentally gets into the eyes
If any of these reactions occur discontinue use and consult a healthcare professional
Comedogenic Rating
Rating: 0 / 5
Rh-Polypeptide-63 is a water-soluble protein molecule with no oily or waxy residues so it does not clog pores. Manufacturers typically add it at very low percentages in lightweight serums or creams which further limits any pore-blocking potential.
This makes Rh-Polypeptide-63 suitable for acne-prone or breakout-prone skin.
As with any ingredient the final formula matters; if Rh-Polypeptide-63 is blended into a rich occlusive base the overall product could still feel heavy on oily skin.
Summary
Rh-Polypeptide-63 is a lab-engineered version of the body’s own SOD2 enzyme that works as a potent antioxidant and skin protector. By neutralizing free radicals it helps fend off fine lines and dullness while calming redness linked to environmental stress.
The peptide shows up mostly in niche anti-aging and pollution-defense products rather than mass market lines, yet its reputation is growing as brands look for gentle alternatives to classic antioxidants like vitamin C.
Current data points to excellent topical safety with minimal irritation risk. Still, every skin type is unique so it is wise to patch test any new product that features this ingredient before full application.