What Is Rh-Polypeptide-65?
Rh-Polypeptide-65 is a lab designed chain of amino acids classified under the code VP8N. It is modeled after naturally occurring peptides that help keep skin and hair proteins intact. Because it is synthesized in a controlled setting rather than harvested from animals or plants, it offers a high level of purity and consistent performance from batch to batch. Production starts with fermenting harmless bacteria or yeast that have been given the genetic instructions to assemble the precise peptide sequence. Once the peptide is expressed it is isolated, purified through filtration and chromatography then freeze-dried into a fine powder ready for cosmetic use.
The beauty industry began exploring bio-engineered peptides in the late 1990s as safer, more targeted alternatives to animal collagen extracts. Rh-Polypeptide-65 gained attention for its ability to coat keratin fibers and mimic some of the skin’s natural protective proteins. Today you will most often spot it in leave-on hair conditioners, strengthening masks, anti-breakage serums, facial moisturizers, barrier repair creams, eye treatments and post-procedure soothing gels.
Rh-Polypeptide-65’s Cosmetic Benefits/Uses
Formulators include Rh-Polypeptide-65 for several performance reasons that focus on conditioning and protection.
- Hair Conditioning: Forms a lightweight film along the hair shaft that smooths the cuticle, reduces frizz and helps retain moisture, leading to softer, more manageable strands.
- Skin Conditioning: Binds water to the skin surface and supports a supple, velvety feel which can enhance the overall sensory profile of a lotion or cream.
- Skin Protecting: Creates a breathable shield that defends against environmental stressors like pollution particles and dry air, helping maintain skin integrity throughout the day.
Who Can Use Rh-Polypeptide-65
Rh-Polypeptide-65 is considered gentle enough for most skin types including dry, normal, combination and sensitive skin. Oily and acne-prone users can generally enjoy it too since the peptide sits lightly on the surface and is not known to clog pores.
The ingredient is produced through microbial fermentation rather than animal extraction so it is suitable for vegans and vegetarians.
Current data shows no specific risk for people who are pregnant or breastfeeding when Rh-Polypeptide-65 is applied topically in cosmetic amounts. This is not medical advice and anyone who is expecting or nursing should run any skincare product past a qualified doctor to be on the safe side.
Rh-Polypeptide-65 does not make skin more sensitive to the sun and can be used alongside daily sunscreen without special timing. It also plays well with most common actives such as vitamin C, niacinamide and retinol.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical use of Rh-Polypeptide-65 can vary from person to person. The points below outline potential issues but they are unlikely to occur for the average user when the ingredient is formulated and used correctly.
- Temporary redness or mild stinging on very sensitive skin
- Itching or small rash in individuals with a peptide allergy
- Watery eyes or irritation if the product accidentally gets into the eye area
- Build-up on fine hair strands that can lead to a weighed-down feel when overused without proper cleansing
If any of these effects appear stop using the product and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0–1
Rh-Polypeptide-65 is a water-soluble peptide that forms a breathable microfilm rather than an occlusive waxy layer, so it does not trap excess sebum or dead skin cells in pores. It also lacks heavy oils and butters that typically rank higher on the comedogenic scale. For these reasons its likelihood of triggering clogged pores sits at the very low end of the scale.
Suitable for acne-prone or breakout-prone skin.
Keep in mind that overall formula matters; pairing this peptide with rich emollients or insufficient cleansing could raise the pore-clogging risk of the finished product.
Summary
Rh-Polypeptide-65 conditions hair by coating and smoothing the cuticle, conditions skin by binding water for a soft feel and protects skin by creating a light protective shield against everyday stressors. It accomplishes this thanks to its lab-designed amino acid sequence that mimics natural proteins and its ability to form a flexible film without heaviness.
While not yet a household name, its versatility and vegan friendly origin have gained steady interest among formulators looking to replace animal peptides or silicone heavy conditioners.
Current evidence shows Rh-Polypeptide-65 is generally safe with a very low irritation and comedogenic profile. As with any new skincare ingredient, perform a patch test when trying a product that contains it to ensure personal tolerance.