S-Cow Oligopeptide-1 Sp: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is S-Cow Oligopeptide-1 Sp?

S-Cow Oligopeptide-1 Sp is a lab made peptide that mimics a short stretch of lactotransferrin, a natural protein found in cow milk. Unlike the full-size protein that has more than seven hundred amino acids, this ingredient contains just thirteen linked in a single chain, making it small enough to sink easily into hair and skin surfaces. Scientists first explored milk proteins for their soothing and strengthening qualities in the early 2000s, and advances in solid phase peptide synthesis soon allowed them to recreate the most useful segments without relying on animal extraction. Today the peptide is built step by step on an automated synthesizer, then purified, dried and added to cosmetic bases.

Because it is both lightweight and flexible, S-Cow Oligopeptide-1 Sp slips readily into water based formulas as well as creams. You will most often see it in leave-on hair conditioners, scalp serums, rinse-out masks, lightweight moisturizers and anti-aging treatments aimed at boosting softness and resilience.

S-Cow Oligopeptide-1 Sp’s Cosmetic Benefits/Uses

When included at the right level this peptide supports the feel and appearance of hair and skin in two key ways

  • Hair Conditioning: The peptide forms a thin, protein rich film that smooths cuticles, reduces static and helps hair strands retain moisture so they look glossier and feel stronger
  • Emollient: On skin the ingredient softens rough patches and improves slip, giving creams and lotions a silkier glide while leaving behind a conditioned, non greasy finish

Who Can Use S-Cow Oligopeptide-1 Sp

This peptide suits most skin and scalp types because it is lightweight, water soluble and non occlusive. Dry or damaged hair benefits from its moisture binding film, while oily and acne-prone skin appreciate that it does not clog pores. Sensitive skin generally tolerates it well since it is free of fragrance and common irritants. No specific skin type is considered incompatible.

S-Cow Oligopeptide-1 Sp is produced entirely by synthetic means, so no animal tissue is used at any point. That makes it suitable for vegans and vegetarians, assuming the finished product is also certified cruelty free.

There is no evidence that the peptide affects hormones or penetrates deeply enough to pose a risk during pregnancy or breastfeeding. Still, this is not medical advice; anyone who is pregnant or nursing should run any new personal care product past a qualified healthcare professional just to be safe.

The ingredient does not increase photosensitivity, so it will not make skin more prone to sunburn. Standard sun protection is still recommended during daytime use of any leave-on product.

Potential Side Effects/Adverse Reactions

Responses to topical S-Cow Oligopeptide-1 Sp vary from person to person. The issues listed below are only potential outcomes and are unlikely for the average user when the ingredient is formulated correctly.

  • Mild redness or stinging on very sensitive skin
  • Localized itching or hives in individuals allergic to milk proteins who also react to the mimicked sequence
  • Contact dermatitis if combined with other irritants in a formula
  • Eye irritation if the product accidentally gets into the eyes
  • Temporary heaviness or dullness in hair if over applied or not rinsed thoroughly

If any of these effects occur stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0/5. S-Cow Oligopeptide-1 Sp is a tiny water-soluble peptide with no oily or waxy components, so it does not sit in pores or create the kind of film that can trap sebum and debris. Its primary role is surface conditioning, and it readily rinses or absorbs without leaving residue. For these reasons it is considered non-comedogenic and is generally well suited to skin that is prone to acne or breakouts. Only if the overall formula contains heavier occlusive ingredients could pore-clogging become a concern.

Summary

S-Cow Oligopeptide-1 Sp works as a hair conditioner and emollient. By forming a light protein film it smooths hair cuticles, reduces static and locks in moisture, while on skin it softens rough areas and improves the slip of creams for a silky afterfeel. Although lab made peptides are not household names yet, this ingredient is gaining quiet popularity among formulators looking for gentle, vegan friendly alternatives to animal proteins.

Safety data show a low risk of irritation or sensitization, and its non-comedogenic nature makes it a comfortable choice for most users. As with any new cosmetic ingredient it is wise to perform a small patch test when trying a product that contains S-Cow Oligopeptide-1 Sp, particularly if you have very sensitive or allergy-prone skin.

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