S-Dna Aptamer-5: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is S-Dna Aptamer-5?

S-DNA Aptamer-5 is a lab-made single stranded DNA fragment made up of 30 nucleotides that folds into a stable three-dimensional shape. Its unique structure lets it cling tightly to glutathione, a natural antioxidant found in skin. Researchers first identified aptamers in the 1990s while looking for easier ways to mimic antibodies, and the beauty industry soon saw their potential for targeted skincare. Today the ingredient is produced with automated DNA synthesizers that build each nucleotide in sequence, then the strand is purified and folded into its active shape. You will most often spot S-DNA Aptamer-5 in lightweight serums, anti-aging creams, hydrating masks, soothing after-sun gels, eye creams and high-performance moisturizers where brands want a precise yet gentle antioxidant boost.

S-Dna Aptamer-5’s Cosmetic Benefits/Uses

The ingredient brings several helpful actions to modern skincare formulas:

  • Antioxidant: Binds glutathione on the skin’s surface, bolstering the skin’s own defense against free radicals created by pollution and UV light which can dull tone and speed up visible aging
  • Reducing agent: Helps keep other sensitive actives such as vitamin C in their most effective state, improving the overall shelf life and punch of the product
  • Humectant: Attracts and holds moisture so skin feels soft, looks plumper and stays comfortable throughout the day
  • Skin protecting: Supports the skin barrier by reducing oxidative stress, which can lessen redness and make skin less prone to dryness or irritation

Who Can Use S-Dna Aptamer-5

S-DNA Aptamer-5 is considered suitable for all major skin types including dry, oily, combination and sensitive skins because it is non greasy, lightweight and free from common irritants such as fragrances or essential oils. There are no known reasons for people with rosacea, eczema or acne prone skin to avoid it, though anyone with a history of reactions to DNA based ingredients should be cautious.

The molecule is manufactured entirely through synthetic DNA synthesis, meaning it contains no animal derived components, so it aligns well with vegan and vegetarian lifestyles. As always check that the finished product was not animal tested if that is a concern.

The current safety data suggests topical S-DNA Aptamer-5 remains on the outer layers of skin and is not systemically absorbed, so it is not expected to pose a risk during pregnancy or breastfeeding. This information is not medical advice and pregnant or nursing individuals should show any prospective skincare product to their physician before use just to be safe.

The ingredient does not induce photosensitivity and can be applied morning or night without increasing sun related risks. It pairs well with sunscreen and with most common actives such as retinoids, acids, peptides and vitamin C.

Potential Side Effects/Adverse Reactions

Side effects and reactions to the topical use of S-DNA Aptamer-5 can vary from person to person. The points below outline potential issues that could occur, although they are uncommon when the ingredient is properly formulated and used as directed.

  • Mild redness or warmth: A temporary flush may appear on very reactive skin when the product is first applied
  • Itching or stinging: Rare and usually brief, more likely if the formula also contains high levels of alcohol or acids
  • Allergic contact dermatitis: Extremely uncommon but possible for individuals sensitized to nucleic acids or certain preservatives used alongside the ingredient
  • Incompatibility with highly acidic products: Very low pH formulas could destabilize the aptamer reducing its effectiveness and potentially causing irritation
  • Contamination risk in poorly preserved products: As a biomolecule it can degrade if the product is contaminated leading to unexpected reactions or loss of efficacy

If you notice persistent irritation, swelling or any other concerning reaction stop using the product and consult a healthcare professional.

Comedogenic Rating

Rating: 0 / 5 – S-DNA Aptamer-5 is a large water-soluble molecule that sits on the skin’s surface without clogging pores. It contains no oils or waxes and does not interact with sebum, so it has virtually no potential to trigger blackheads or breakouts.

Because of this rating the ingredient is considered suitable for acne-prone and breakout-prone skin types.

Like most water-based actives its comedogenicity can only change if it is blended into a very heavy or greasy base, so look at the entire formula if you are highly sensitive to pore-clogging ingredients.

Summary

S-DNA Aptamer-5 acts as an antioxidant, reducing agent, humectant and skin protectant. Its folded DNA structure locks onto glutathione to neutralize free radicals, keeps delicate actives like vitamin C in their active state, draws moisture to the skin and lessens oxidative stress that can weaken the barrier.

While still a niche addition compared with retinol or hyaluronic acid it is gaining attention in premium serums and eye creams for providing targeted antioxidant power without heaviness.

Current research and product feedback show it to be very safe for topical use with few reports of irritation or sensitization. As with any new skincare ingredient it is wise to perform a quick patch test before applying it all over the face to ensure personal compatibility.

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