S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate?

S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate is a lab-made chain of ten amino acids that comes from a small part of the T4 bacteriophage, a virus that infects bacteria. Scientists first studied this viral protein fragment for its talent at finding and binding damaged spots in DNA, then discovered its calming and conditioning effects on skin when used on the surface. To make the ingredient, chemists build the peptide step by step in a controlled reactor, attach a trifluoroacetate counterion to keep it stable, then purify the final powder before blending it into cosmetic bases.

You will usually spot this peptide in lightweight serums, anti-aging creams, sheet masks, eye treatments and after-sun gels where brands want a gentle yet effective skin conditioner.

S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate’s Cosmetic Benefits/Uses

This ingredient carries one main job in skincare formulas:

Skin conditioning: It helps the outer layer of skin feel softer and smoother, supports a healthy moisture barrier and gives a refreshed look that can make the complexion appear more even and calm.

Who Can Use S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate

This lab made peptide is generally gentle enough for all skin types, including dry, oily, combination and sensitive skin, because it does not contain common irritants like fragrance or alcohol and works at skin friendly pH levels. Extremely reactive or allergy prone skin should still keep an eye on the ingredients list in case the finished formula pairs the peptide with harsher actives.

The peptide is made entirely by chemical synthesis so it is suitable for both vegans and vegetarians. No animal derived materials are used at any step of production.

Based on current data, the ingredient is considered low risk for women who are pregnant or breastfeeding when applied topically and in normal cosmetic concentrations. This is not medical advice and expecting or nursing mothers should show any new product to their healthcare provider before adding it to a routine.

S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate does not make skin more sensitive to sunlight and can be used day or night without raising the risk of sunburn. Standard sunscreen use is still recommended whenever spending time outdoors.

Because the peptide simply conditions the skin, it can be layered alongside most other actives like vitamin C, niacinamide or retinol without known conflicts.

Potential Side Effects/Adverse Reactions

Responses to topical S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate differ from person to person. The list below covers potential reactions only and they are unlikely for the average user when the ingredient is properly formulated and used as directed.

  • Transient redness
  • Mild stinging or warmth right after application
  • Localized irritation in people with very sensitive skin
  • Allergic contact dermatitis for those allergic to any component of the finished formula
  • Watery eyes if a high strength eye treatment migrates into the eye area

If any persistent discomfort or rash develops stop using the product and consult a healthcare professional for personalized guidance.

Comedogenic Rating

Rating: 0 / 5

S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate is a tiny water-soluble peptide that absorbs quickly and leaves no oily film so it does not clog pores. It contains no heavy oils, waxes or fatty alcohols that normally trigger breakouts. Because of this the ingredient is considered non-comedogenic and is suitable for acne-prone or congested skin.

Since the peptide is usually used at very low percentages within lightweight formulas it is unlikely to change the overall pore-clogging potential of a finished product.

Summary

S-Enterobacteria Phage T4 Decapeptide-1 Sp Trifluoroacetate is a lab-crafted ten-amino-acid peptide prized for its skin-conditioning talent. By binding to the surface it helps smooth texture, reinforce the moisture barrier and lend a calmer more even look to the complexion. Brands add it to serums creams and masks when they want gentle support without heaviness.

Right now this peptide is still a niche pick compared with buzzier actives like retinol or vitamin C, yet its mild nature and versatility are earning it a quiet following among formulators who cater to sensitive or post-treatment skin.

Available safety data shows it is low risk for most users with no known long-term concerns. As with any new skincare ingredient it is smart to perform a quick patch test before full-face use to rule out individual sensitivities.

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