What Is S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide?
S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide is a lab-made peptide modeled after temporin-1Tl, a small protein first found in the skin of a tree frog. Chemists took the most active part of that natural protein, rebuilt it with a mix of eight amino acids, then added two mirror-image forms of leucine and lysine plus a short three-amino-acid chain capped with an amide group. This tweak keeps the peptide stable and skin friendly.
The beauty industry became interested in temporin-based peptides in the early 2000s when studies showed they could fight blemish-causing microbes without the harsh feel of classic preservatives. By switching to a fully synthetic build, makers avoid harvesting from frogs and can control purity batch after batch.
Production starts with solid-phase peptide synthesis. Each amino acid is added one at a time in a set order, then the chain is released, purified through filtration and chromatography, and dried into a fine powder. The result dissolves easily in water or light oils, making it simple to blend into finished formulas.
You will usually see this ingredient in clarifying toners, lightweight moisturizers, leave-on spot treatments, sheet masks and multifunction serums aimed at balancing oil while keeping skin calm.
S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide’s Cosmetic Benefits/Uses
When added to skincare, this peptide offers several useful actions that help keep formulas effective and skin looking its best.
- Anti-Sebum – helps curb excess oil on the surface so skin feels fresh and looks less shiny
- Antimicrobial – targets blemish-causing bacteria which supports clearer skin and extends product freshness
- Preservative – boosts the formula’s resistance to spoilage, reducing the need for stronger synthetic preservatives
- Skin Protecting – forms a light barrier that shields from everyday stressors and helps maintain a healthy moisture balance
Who Can Use S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide
This peptide is generally well tolerated by all skin types. Oily and combination skin often see the most benefit because of the oil-balancing action, while normal skin gains a light protective boost. Dry or very sensitive skin can use it too, provided the overall formula offers enough hydration and is free from harsh solvents that could amplify dryness.
The ingredient is entirely synthetic and contains no animal-derived matter, so it fits vegan and vegetarian lifestyles.
No specific warnings exist for pregnant or breastfeeding women, but research on this exact peptide is limited. This content is not medical advice; anyone who is pregnant or nursing should show the full ingredient list of any product to a healthcare professional before adding it to a routine.
S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide does not make skin more sensitive to sunlight, so it does not raise the risk of sunburn. Standard daytime SPF use is still recommended with any skincare program.
The peptide is water soluble and plays well with common actives like niacinamide, hyaluronic acid and gentle exfoliating acids, making it easy to fit into multi-step routines.
Potential Side Effects/Adverse Reactions
Reactions to topical S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide vary from person to person. The points below outline potential issues that could occur, though most users experience none when the ingredient is formulated and used correctly.
- Mild skin irritation – transient tingling or warmth after application
- Redness – temporary flushing, especially on very reactive skin
- Dry patches – possible if the product lacks adequate moisturizers for naturally dry skin
- Allergic contact dermatitis – rare cases of itching, hives or swelling for those sensitive to specific peptides
- Stinging on compromised skin – open cuts or active eczema may feel a slight burn when the peptide solution is applied
If any of these reactions occur, stop using the product and consult a qualified healthcare provider.
Comedogenic Rating
Rating: 0 out of 5. S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide is a small, water-soluble peptide that does not leave an occlusive film on the skin, so it will not trap oil or debris inside pores. Its antimicrobial action can even discourage the bacteria that contribute to breakouts, which further lowers any clogging risk.
Suitable for acne-prone or congestion-prone skin.
Because this peptide is usually included at low concentrations and is often paired with light vehicles such as gels or serums, the overall formula is unlikely to shift the comedogenic profile of a product.
Summary
S-Frog Octapeptide-1 D-Leucyl D-Lysyl Tripeptide-90 Amide balances oil, curbs blemish-causing microbes, boosts preservative systems and leaves a thin protective layer that helps retain moisture. It achieves these benefits by mimicking a naturally defensive frog peptide, disrupting bacterial membranes, binding excess surface sebum and integrating into formulas as a mild co-preservative.
The ingredient is still niche compared with big-name actives like niacinamide and retinol, but its gentle multitasking profile is winning attention in newer clarifying serums and spot treatments.
Current data suggest it is low risk for irritation or clogged pores, though individual sensitivities are always possible. As with any new skincare ingredient, patch testing a finished product first is a smart step before full-face use.