What Is S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp?
S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp is a lab-made peptide made up of 36 linked amino acids. It combines two short fragments modeled after the envelope protein of the HIV-1 virus with an added lysine residue that helps keep the chain stable and water friendly. Because it is fully synthetic no animal or plant material is used in its production.
The ingredient is produced through solid-phase peptide synthesis, a step-by-step method where each amino acid is added in a controlled sequence then the finished chain is purified and dried into a fine powder. Peptide research took off in the late 1990s as scientists looked for small, skin-friendly molecules that could mimic growth factors without the instability of full proteins. This particular hybrid peptide was developed to target skin resilience and to act as a protective film on the surface, gaining traction in premium skincare labs during the last decade.
Today you will most often spot S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp in anti-aging serums, firming creams, sheet masks, eye treatments, post-procedure soothing gels and concentrated booster ampoules. Brands choose it when they want a lightweight yet active peptide that can sit comfortably in water-based formulas.
S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp’s Cosmetic Benefits/Uses
Formulators reach for this peptide because it offers two helpful functions that support healthier looking skin.
- Skin conditioning – the peptide attracts water and holds it near the surface so skin feels softer and looks plumper. Over time regular use can improve texture and give a smoother finish.
- Skin protecting – once applied it forms a light breathable film that helps defend skin from daily irritants such as pollution or friction. This shield also slows moisture loss which can reduce dryness and redness.
Who Can Use S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp
This peptide is gentle enough for nearly all skin types. Normal, dry, combination and oily skin can benefit from its light hydrating film. Sensitive or reactive skin often tolerates it well because the molecule is non acidic and free of fragrance, but anyone with a known allergy to peptides should be cautious. It is water based so it will not add extra oil to acne prone skin.
Because the ingredient is fully synthetic and produced without animal by-products it is suitable for both vegans and vegetarians.
No studies show that topical use of this peptide affects hormones or crosses into the bloodstream at levels that would worry doctors, so most brands consider it safe during pregnancy or while breastfeeding. This is not medical advice and pregnant or nursing users should always confirm any skincare choice with their physician.
The peptide does not make skin more sensitive to sunlight and has no known interaction with UV filters, so daytime use is fine provided a regular sunscreen is still applied.
It can be paired with most common actives such as niacinamide, vitamin C or retinol without stability issues. Formulas often include it in multi-peptide blends for an added conditioning boost.
Potential Side Effects/Adverse Reactions
Responses to topical S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp differ from person to person. The points below outline potential effects that might appear in rare cases. When manufactured and used correctly most people will not notice any problems.
- Mild redness or warmth shortly after application
- Temporary stinging or itching on very sensitive skin
- Localized swelling if an individual is allergic to peptide structures
- Dry patches if the formula also contains a high level of alcohol
- Interaction with leave-on exfoliating acids that could heighten irritation
If any discomfort or visible reaction develops stop using the product and consult a healthcare professional if symptoms persist.
Comedogenic Rating
Rating: 0/5 – S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp is a small water-soluble peptide that does not leave an oily or occlusive residue, so it has virtually no pore-clogging potential on its own.
Because of this rating, the ingredient is generally considered suitable for skin that is prone to acne or frequent breakouts.
Keep in mind that a finished product’s overall comedogenicity depends on the full formula, not just this single peptide.
Summary
S-Hiv-1 Oligopeptide-4 Sh-Oligopeptide-87 Lysine Sp conditions skin by binding water to the stratum corneum then forms a light film that protects against external stressors and slows moisture loss. Its synthetic 36-amino-acid chain is stable, vegan friendly and comfortable in water-based systems.
The peptide is gaining traction in high-end serums and masks yet it is still a niche option compared with classic actives like hyaluronic acid or retinol. Brands value its gentle profile and compatibility with other ingredients.
Current data show it is low risk for irritation, non-comedogenic and safe for most usersincluding those who are pregnant or breastfeedingbut anyone trying a new product should still perform a quick patch test to rule out personal sensitivity.