Safflower Seed Oil Polyglyceryl-6 Esters: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Safflower Seed Oil Polyglyceryl-6 Esters?

Safflower Seed Oil Polyglyceryl-6 Esters is a plant-derived ingredient created by joining safflower seed oil with a short chain of glycerin molecules. The process, called transesterification, links the fatty acids found in Carthamus tinctorius (safflower) oil to a glycerol homopolymer that averages six glycerin units. The result is a silky liquid that mixes well with both oils and water.

Safflower oil has been pressed and used for centuries as a cooking and skin softening oil. Chemists later discovered that bonding its fatty acids to polyglycerin improved stability and made it easier to blend into modern cosmetic formulas. This upgraded form first appeared in natural skin care lines looking for plant sourced emulsifiers. Today it is produced in controlled reactors where safflower oil and polyglycerin are gently heated with a catalyst, then purified to remove trace salts and free glycerin.

You will find Safflower Seed Oil Polyglyceryl-6 Esters in a wide range of products such as facial and body moisturizers, cleansing balms, makeup removers, sheet masks, leave-on conditioners and soothing baby lotions. Its ability to both soften skin and keep oil and water mixed makes it popular in lightweight serums as well as rich creams.

Safflower Seed Oil Polyglyceryl-6 Esters’s Cosmetic Benefits/Uses

This multitasking ingredient supports formulas in several helpful ways:

  • Emollient: Coats the skin with a thin protective layer that smooths rough patches and reduces moisture loss giving a soft supple feel
  • Cleansing: Loosens makeup sunscreen and daily grime so they rinse away more easily without stripping the skin
  • Emulsifying: Helps oil and water stay blended creating stable lotions and creams that maintain an even texture over time

Who Can Use Safflower Seed Oil Polyglyceryl-6 Esters

This ingredient suits most skin types including dry oily combination and sensitive because it feels lightweight yet still seals in moisture without leaving a greasy film. Its low tendency to clog pores makes it a friendly choice for acne-prone complexions unless an individual already knows they react poorly to vegetable oils.

Safflower Seed Oil Polyglyceryl-6 Esters is entirely plant based. Both the safflower oil and the polyglycerin backbone are derived from renewable botanical sources so it is appropriate for vegans and vegetarians.

No published data suggest a risk for pregnant or breastfeeding women when the ingredient is used in rinse-off or leave-on cosmetics. Absorption through intact skin is minimal yet this is not medical advice and anyone who is expecting or nursing should ask a healthcare professional before adding new products to their routine.

The ingredient does not make skin more sensitive to sunlight and it is fragrance free by nature which can be helpful for people avoiding perfumed formulas.

Potential Side Effects/Adverse Reactions

Skin responses vary from person to person. The points below describe potential side effects which are uncommon when the ingredient is formulated and used correctly.

  • Allergic contact dermatitis in individuals sensitive to safflower ragweed or related plants
  • Mild redness or stinging on very reactive skin especially if applied to broken or compromised barrier
  • Rare clogged pores or small breakouts in users who are extremely acne prone
  • Eye irritation if a high concentration gets into the eyes during cleansing

If any irritation or adverse reaction occurs stop using the product and consult a qualified healthcare provider.

Comedogenic Rating

Rating: 1 out of 5

The base oil in this ester, safflower seed oil, is naturally low in oleic acid which reduces its pore-clogging potential. Turning it into a polyglyceryl-6 ester makes the molecules even more water compatible so they spread in a thinner layer and rinse away more easily. Together these factors keep buildup inside pores to a minimum.

Most people prone to acne can use products containing Safflower Seed Oil Polyglyceryl-6 Esters without seeing extra breakouts though those with extremely reactive or very oily skin may still prefer spot-testing first.

Formulation matters: a rich cream packed with other heavy oils may still feel occlusive even if this single ingredient is low on the scale.

Summary

Safflower Seed Oil Polyglyceryl-6 Esters acts as an emollient that smooths and softens skin a gentle cleanser that lifts makeup and grime and an emulsifier that holds oil and water together for a stable silky texture. It does this by combining the lightweight fatty acids of safflower oil with a short chain of glycerin units giving it the ability to interact with both lipids and water.

The ingredient has carved out a steady place in modern skin and hair care especially among clean beauty lines looking for plant-derived multifunctional agents though it is not yet as mainstream as classic emulsifiers like glyceryl stearate.

Overall safety data are strong with low irritation and low comedogenicity reported. As with any new cosmetic ingredient it is wise to patch test a product before full use to make sure it suits your individual skin needs.

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