What Is Sh-Decapeptide-23?
Sh-Decapeptide-23 is a lab made version of a small piece of the human protein angiotensinogen. Scientists copy ten specific amino acids—arginine, aspartic acid, histidine, isoleucine, leucine, phenylalanine, proline, tyrosine and valine—then link them in the same order found in our bodies. The result is a single chain peptide that is identical to what the body could make but is produced entirely in a controlled facility. Most manufacturers rely on solid phase peptide synthesis, a step by step process that builds the chain one amino acid at a time. After the chain is finished it is purified, tested for safety and blended into skincare formulas.
The idea of using such short peptides in cosmetics grew popular in the early 2000s when researchers noticed that targeted chains of amino acids could send helpful signals to skin. Sh-Decapeptide-23 was developed to bring antioxidant and protective benefits without the instability of plant extracts or vitamins. Because it is water soluble and works well at low levels it slips into many product types. You will find it in sheet masks, anti aging serums, daily moisturizers, eye creams, soothing after sun gels and leave on night treatments.
Sh-Decapeptide-23’s Cosmetic Benefits/Uses
Formulators choose Sh-Decapeptide-23 for two main reasons
- Antioxidant: Helps neutralize free radicals produced by UV light and pollution which can lead to dullness and early wrinkles. This support keeps skin looking fresher for longer
- Skin protecting: Strengthens the surface barrier so skin can hold moisture better and feel less sensitive when faced with stressors like wind heat or harsh cleansers
Who Can Use Sh-Decapeptide-23
Because it is lightweight and water soluble Sh-Decapeptide-23 suits nearly every skin type including oily, dry, combination and mature skin. Sensitive skin typically tolerates it well thanks to its gentle, fragrance-free nature. There are presently no known reasons for people with acne-prone or rosacea-prone skin to avoid it
The peptide is produced entirely in a lab without any animal-derived materials so it is considered suitable for both vegans and vegetarians
Current data does not link topical Sh-Decapeptide-23 to reproductive or hormonal concerns. Pregnant or breastfeeding individuals can generally use products containing it but this is not medical advice and anyone expecting or nursing should check with a healthcare professional before adding new skincare
Sh-Decapeptide-23 does not make skin more sensitive to sunlight and it can be used morning or night with or without SPF. It also plays well with most common ingredients including niacinamide, hyaluronic acid, vitamin C and sunscreens
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Decapeptide-23 differ from person to person. The points below list potential side effects yet most users experience none of them when the ingredient is formulated and used correctly
- Transient redness or warmth
- Mild stinging or itching at the application site
- Rare allergic contact dermatitis
- Interaction with other strong actives causing increased sensitivity if overlayered too quickly
If any negative reaction occurs stop using the product and consult a healthcare professional
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Sh-Decapeptide-23 is a small, water-soluble peptide that does not contain heavy oils, waxes or fatty acids that typically clog pores. It absorbs easily and leaves no occlusive film, which is why formulators classify it as non-comedogenic.
That makes the ingredient a comfortable choice for people who are prone to acne or breakouts.
As always the final product matters. If Sh-Decapeptide-23 is blended into a rich balm or thick cream the other ingredients, not the peptide itself, could influence pore clogging potential.
Summary
Sh-Decapeptide-23 serves as an antioxidant and skin-protecting agent. By neutralizing free radicals it helps limit early signs of aging while its barrier-supporting action keeps moisture in and outside stressors out. The peptide achieves these effects by mimicking a natural fragment of angiotensinogen which allows it to communicate smoothly with skin cells without irritation.
This is still a niche ingredient so you will spot it in select serums, masks and moisturizers rather than on every shelf. Interest is growing as brands look for stable, lab-made options that perform like plant extracts but with fewer preservation challenges.
Current research and use reports show Sh-Decapeptide-23 to be safe for most skin types with minimal risk of side effects. Even so it is wise to patch test any new product to confirm personal compatibility before full-face application.