What Is Sh-Heptapeptide-13?
Sh-Heptapeptide-13 is a lab-made copy of a short human protein called angiotensin 1. Scientists string together seven specific amino acids – arginine, aspartic acid, histidine, isoleucine, proline, tyrosine and valine – to recreate this tiny piece of a much larger natural protein known as angiotensinogen. Because it is made through controlled fermentation or solid-phase peptide synthesis, the finished ingredient is free of animal material and can be produced in large, consistent batches.
The beauty industry first became interested in this peptide when research showed that fragments of angiotensinogen could help shield skin cells from everyday stress. Formulators soon began adding the synthetic version to anti-aging serums and creams, looking to pair its defending action with other proven ingredients like vitamins C and E. Today you will spot Sh-Heptapeptide-13 in moisturizers, firming masks, lightweight eye gels, leave-on treatments and even some sunscreens where it works alongside UV filters.
Sh-Heptapeptide-13’s Cosmetic Benefits/Uses
This peptide brings two main actions to a skincare formula
- Antioxidant – helps neutralize free radicals triggered by pollution, sunlight and everyday stress. By cutting down these unstable molecules it can reduce the look of dullness and keep other sensitive ingredients like natural oils from breaking down too fast
- Skin protecting – forms a supportive shield on the surface of the skin that limits damage from external irritants. This protective role can ease redness, improve overall resilience and make the skin feel smoother and more comfortable
Who Can Use Sh-Heptapeptide-13
Because Sh-Heptapeptide-13 is lightweight, fragrance free and non greasy it tends to suit almost every skin type including dry, oily, combination and even easily upset sensitive skin. The molecule itself is non comedogenic so it should not clog pores, making it a safe pick for acne prone users as well. There are no known skin types that must completely avoid it, though anyone with a history of peptide allergies should proceed with caution.
The ingredient is made entirely through lab fermentation or solid phase synthesis with no animal derived materials, so it aligns with vegan and vegetarian lifestyles.
Current data shows no specific risk for people who are pregnant or breastfeeding. Still, research in these groups is limited. This is not medical advice and anyone who is expecting or nursing should discuss all personal care products with a qualified healthcare professional just to be on the safe side.
Sh-Heptapeptide-13 does not absorb UV light and does not make skin more prone to sunburn. It can be used morning or night, with or without sunscreen layered on top.
The peptide plays nicely with most other common actives such as niacinamide, vitamin C and retinoids so it fits easily into a wide range of routines.
Potential Side Effects/Adverse Reactions
Individual responses to Sh-Heptapeptide-13 can vary. The points below cover potential issues that could occur, but they are uncommon when the finished product has been properly formulated and preserved.
- Mild redness or warmth at the application site
- Temporary itching or stinging, especially on very dry or compromised skin
- Rare allergic reaction presenting as rash swelling or hives
- Occasional breakouts if the formula pairs the peptide with heavy occlusive ingredients even though the peptide itself is non comedogenic
- Heightened sensitivity to other strong actives if applied in the same routine because the peptide can slightly enhance ingredient penetration
If any uncomfortable reaction develops discontinue use and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Heptapeptide-13 is a small, water-friendly molecule that does not leave an oily film or linger inside pores, so it carries virtually no risk of clogging them. Its structure is very different from heavier plant butters or waxes that can trap sebum. As a result, it is generally suitable for people who are prone to acne or breakouts.
Keep in mind that a finished product may still cause congestion if it pairs the peptide with rich emollients or thick silicones. Always look at the full ingredient list when assessing a formula’s pore-clogging potential.
Summary
Sh-Heptapeptide-13 works as an antioxidant and a skin protectant. It scavenges free radicals created by UV light and pollution which helps prevent dullness and early signs of aging. At the same time it forms a light protective veil that supports the skin barrier and reduces everyday irritation.
The peptide is gaining traction but is not yet as common as classics like niacinamide or vitamin C. You will mostly find it in mid to high-end serums and moisturizers aimed at boosting resilience and keeping skin calm.
Current data shows it to be low risk for irritation or sensitization. Still, everyone’s skin is unique so perform a quick patch test when trying any new product containing Sh-Heptapeptide-13 to make sure it agrees with you.