What Is Sh-Hexapeptide-43?
Sh-Hexapeptide-43 is a lab made peptide that copies a small part of the body’s own Stem Cell Factor protein. It is built from six amino acids in a set sequence: asparagine, isoleucine, leucine, lysine and valine. Because it is produced synthetically in controlled facilities, it is free of animal or plant material and remains consistent from batch to batch.
Peptides that mimic natural skin signals started gaining attention in the early 2000s as scientists searched for gentler options to support skin health. Sh-Hexapeptide-43 emerged from this wave of research. By isolating a tiny but active fragment of a larger protein, chemists were able to deliver targeted benefits in a stable form that blends well with water based formulas.
The manufacturing process relies on solid phase peptide synthesis, where each amino acid is added step by step to create the exact chain. After the chain is complete it is purified, dried into a fine powder then added to cosmetic bases at low concentrations.
You will most often find Sh-Hexapeptide-43 in lightweight serums, daily moisturizers, anti aging creams, sheet masks, eye treatments and soothing after sun products. Brands use it as a modern alternative to plant extracts when they want predictable performance and low risk of irritation.
Sh-Hexapeptide-43’s Cosmetic Benefits/Uses
This ingredient is prized for one main role in skin care formulas.
Skin protecting: Sh-Hexapeptide-43 supports the skin’s natural barrier by encouraging a balanced surface environment. A stronger barrier helps the skin hold on to moisture, feel less tight and better resist outside stress like pollution or harsh weather. When included in a formula it can make the end product feel more comforting and suitable for sensitive or freshly exfoliated skin.
Who Can Use Sh-Hexapeptide-43
Sh-Hexapeptide-43 is generally well tolerated by all major skin types including dry, oily, combination and sensitive skin because it focuses on fortifying the surface rather than exfoliating or heavily stimulating it. There are no known reasons it would be unsuitable for any particular skin type unless a person has a specific allergy to one of its amino acid components, which is rare.
The peptide is made entirely by synthetic methods without animal or plant material, so it aligns with vegan and vegetarian lifestyles. Many brands that feature it also avoid animal testing, further supporting cruelty free preferences.
Current research has not flagged Sh-Hexapeptide-43 as unsafe for those who are pregnant or breastfeeding, yet comprehensive human studies are limited. This material is not intended as medical advice and anyone who is pregnant or nursing should show any product containing Sh-Hexapeptide-43 to a qualified health professional before use to stay on the safe side.
The ingredient does not raise the skin’s sensitivity to sunlight, and it can be applied morning or night without increasing the need for extra UV protection beyond a normal daily sunscreen. It also plays nicely with most other common skin care actives, making it easy to slot into existing routines.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Hexapeptide-43 vary from person to person. The points below list potential reactions, but most users will not encounter these issues when the ingredient is used at standard cosmetic levels.
- Temporary redness – a mild flush that fades after application
- Itching or tingling – usually short lived and low intensity
- Dry patches – very uncommon and often related to other formula components
- Allergic contact dermatitis – rare but possible in individuals with peptide sensitivities
- Interaction with broken skin – may cause slight stinging if applied to fresh cuts or abrasions
If any persistent discomfort, swelling or rash occurs stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sh-Hexapeptide-43 is a small water-soluble peptide that contains no oils, waxes or fatty acids that could block pores. Its primary role is to support the skin barrier rather than coat the surface, so it leaves behind no residue that might trap sebum or dead skin cells. Peptides of this type are typically used at very low concentrations, further reducing any chance of congestion.
Because of this it is generally suitable for people who are prone to acne or frequent breakouts.
The only caveat is the product base it sits in. If the surrounding cream or serum relies on heavier emollients the finished formula, not the peptide itself, could be comedogenic. Always check the overall ingredient list when pore clogging is a concern.
Summary
Sh-Hexapeptide-43 is a lab crafted six-amino-acid fragment that mimics part of the body’s Stem Cell Factor protein. In skincare it acts mainly as a skin protector by encouraging a balanced surface environment that keeps moisture in and outside stress out. Its tiny size lets it blend easily into lightweight water-based formulas while remaining stable.
The peptide is still a niche addition compared to blockbuster ingredients like niacinamide or hyaluronic acid yet it is gaining quiet popularity with brands that focus on gentle barrier care and vegan formulation.
Safety data to date shows it is well tolerated across skin types with a very low risk of irritation. As with any new cosmetic ingredient it is smart to perform a simple patch test before full use to confirm personal compatibility.