What Is Sh-Oligopeptide-27 Sp?
Sh-Oligopeptide-27 Sp, also known as Synaptobrevin-2 or VAMP2, is a lab-made short chain of amino acids modeled after a protein that helps nerve cells communicate. Skincare chemists recreate this fragment through controlled peptide synthesis, stringing together its amino acids one by one in a sterile facility. The finished material is purified then blended into water-based cosmetic formulas.
Interest in bioactive peptides began in the early 2000s when brands looked for gentle yet effective anti-aging options. Researchers noticed that snippets of the Synaptobrevin-2 protein could signal skin cells to look smoother and better hydrated. After safety testing the peptide was introduced to the market under the name Sh-Oligopeptide-27 Sp and has since found a place in many modern formulations.
You will usually spot this ingredient in lightweight serums, anti-aging creams, sheet masks, eye gels, soothing post-treatment balms and daily moisturizers aimed at boosting softness and resilience.
Sh-Oligopeptide-27 Sp’s Cosmetic Benefits/Uses
This peptide brings several useful traits to a skincare formula
- Skin conditioning: Helps skin feel smoother and look more even by supporting the surface layers and encouraging a fresh appearance
- Emollient: Adds a soft touch that improves spreadability and leaves a delicate, silky finish without heaviness
- Skin protecting: Forms a light barrier that defends against everyday environmental stress so skin stays comfortable and less reactive
Who Can Use Sh-Oligopeptide-27 Sp
Because it is light, water-soluble and non-greasy, Sh-Oligopeptide-27 Sp works well for nearly every skin type including oily, dry, combination and mature skin. Even sensitive skin generally tolerates the peptide since it is fragrance-free and used at low concentrations, though people with very reactive complexions may prefer to introduce it gradually to be sure their skin agrees with it.
The peptide is produced entirely through plant-free, animal-free laboratory synthesis so it fits vegan and vegetarian lifestyles without issue.
No data suggest the ingredient is problematic during pregnancy or breastfeeding. That said, this information is not medical advice and anyone who is pregnant or nursing should review any new skincare product with a qualified healthcare professional before use.
Sh-Oligopeptide-27 Sp does not make skin more sensitive to sunlight and can be applied morning or night without affecting photosensitivity. It also plays nicely with common actives like niacinamide, hyaluronic acid and gentle exfoliating acids, letting you slot it into most routines without extra precautions.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Oligopeptide-27 Sp can vary from person to person. The points below list potential issues that could occur, but they are uncommon when the ingredient has been properly formulated and used as directed.
- Mild redness or warmth immediately after application, usually short-lived
- Temporary tingling or stinging on very sensitive or compromised skin
- Rare cases of contact dermatitis in individuals allergic to one of the formula’s other components
- Breakouts if the finished product contains heavy occlusives unsuited to acne-prone skin
- Eye irritation if the product is applied too close to the lash line
If you experience persistent irritation or any unexpected reaction discontinue use and consult a healthcare professional
Comedogenic Rating
Rating: 0
Sh-Oligopeptide-27 Sp is a tiny water-soluble peptide that leaves no oily residue and does not block pores, so it sits at the bottom of the comedogenic scale. Its job is to condition and protect, not occlude. Because it is used at very low levels and lacks heavy lipids its chance of clogging pores is virtually nil.
That makes it suitable for skin prone to acne or breakouts.
Only the other ingredients in a finished product, such as thick butters or waxes, would change the pore-clogging potential so always judge the full formula.
Summary
Sh-Oligopeptide-27 Sp is a lab-crafted peptide that conditions skin, smooths texture, adds a light emollient feel and helps defend the surface from everyday stress. It performs these tasks by sending calming signals to skin cells and forming a sheer protective film that locks in moisture without weight.
While not as famous as peptides like Matrixyl or Argireline it is gaining quiet popularity among formulators who want a gentle multitasker that plays well with most actives.
Current research and practical use show the ingredient to be low risk with only rare mild irritation reported. As with any new skincare product a quick patch test is still the smart move before full-face use.