What Is Sh-Oligopeptide-70?
Sh-Oligopeptide-70 is a lab-made fragment of fibroblast growth factor 7, a protein naturally present in human skin that keeps cells active and resilient. Chemically, it is a chain of 21 amino acids arranged in the exact order found in the original protein, so skin tissues recognize it as familiar. By isolating this small section, scientists captured useful skin-supporting signals while avoiding the instability of the full-size molecule.
The peptide is produced through solid-phase peptide synthesis, a step-by-step process that links amino acids on a resin, then releases and purifies the finished chain. The resulting white powder dissolves in water and blends easily into cosmetic bases, giving formulators a stable high-purity ingredient.
Peptides that mimic growth factors rose to fame in the early 2000s when brands searched for gentle alternatives to animal extracts. Sh-Oligopeptide-70 gained popularity because it is fully synthetic, cruelty-free and compatible with common preservatives and pH ranges. Today it is featured in many premium anti-aging collections.
You will find it in lightweight serums, sheet masks, eye gels, moisturizers and leave-on ampoules designed to smooth texture, refresh dull complexions and support overall skin appearance.
Sh-Oligopeptide-70’s Cosmetic Benefits/Uses
In skincare formulas Sh-Oligopeptide-70 serves one main role:
Skin conditioning: By supporting healthy surface cell turnover and moisture balance, this peptide helps skin feel softer smoother and more supple, which can make the complexion look fresher and enhance the performance of other actives.
Who Can Use Sh-Oligopeptide-70
Thanks to its lightweight water-soluble nature and gentle profile, Sh-Oligopeptide-70 suits most skin types including dry, normal, combination and oily. Sensitive skin users generally tolerate it well because it is fragrance free and produced at high purity, though anyone with a history of peptide allergies should stay cautious.
Because the peptide is created entirely through synthetic chemistry and contains no animal-derived materials, it is appropriate for both vegans and vegetarians.
Current research shows no specific issues for women who are pregnant or breastfeeding when this ingredient is applied topically in cosmetic concentrations. This is not medical advice so expectant or nursing mothers should still ask their healthcare provider before adding any new skincare product, just to be safe.
Sh-Oligopeptide-70 does not increase photosensitivity and can be used morning or night without elevating the risk of sunburn. As with any leave-on active, pairing daytime use with broad-spectrum sunscreen is good overall practice.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-70 vary from person to person. The points below list potential side effects that could occur, but most people experience none of these when the ingredient is formulated and used correctly.
- Temporary redness or flushing
- Mild itching or stinging on application
- Localized dryness if paired with over-exfoliation
- Rare allergic contact dermatitis in individuals sensitive to peptides or preservatives in the finished formula
If any of these reactions appear and do not calm quickly after rinsing, stop using the product and consult a skincare professional or physician.
Comedogenic Rating
Rating: 0/5
Sh-Oligopeptide-70 is a small, water-soluble peptide that contains no heavy oils, waxes or fatty acids so it does not clog pores or trap sebum. Its molecular size and hydrophilic nature allow it to rinse away cleanly if layered under other products, which keeps pore blockages unlikely.
This makes the ingredient suitable for skin that is prone to acne or breakouts.
Any comedogenic risk comes more from the overall formula than from the peptide itself, so check the full ingredient list if congestion is a concern.
Summary
Sh-Oligopeptide-70 is a lab-crafted fragment of fibroblast growth factor 7 that conditions skin by encouraging healthy surface cell renewal and supporting moisture balance. By mimicking a native signaling protein, it helps skin look smoother, feel softer and appear more vibrant without the instability of the full growth factor.
The peptide has found a steady following in higher-end anti-aging serums, masks and eye products, though its cost keeps it from mass-market formulas. Users value it for being vegan friendly, fragrance free and gentle across most skin types.
Topical safety data are favorable with only rare reports of mild irritation. Still, everyone’s skin is unique so perform a patch test when trying any new product that contains Sh-Oligopeptide-70 just to stay on the safe side.