What Is Sh-Oligopeptide-71?
Sh-Oligopeptide-71 is a lab-created version of the naturally occurring peptide dynorphin A. Scientists identified a short fragment of this brain-derived protein that could benefit skin when applied topically, then reproduced it through solid-phase peptide synthesis, a method that strings amino acids together in a precise order. Because the peptide is made in a controlled pharmaceutical-grade environment, it is both highly pure and consistent from batch to batch.
The ingredient first drew interest in dermatology labs investigating how certain neuropeptides influence skin oil production and barrier health. As research progressed formulators recognized its potential to help balance sebum and shield skin from everyday stress, leading to its inclusion in cosmetic products over the past decade. You can now find Sh-Oligopeptide-71 in lightweight serums, anti-blemish moisturizers, mattifying primers, sheet masks targeting oily zones and leave-on treatments designed to keep complexions calm and clear.
Sh-Oligopeptide-71’s Cosmetic Benefits/Uses
Formulators choose Sh-Oligopeptide-71 for two key reasons
- Anti-Sebum: The peptide helps moderate excess oil by signaling sebaceous glands to dial back production. Regular use may lead to a more balanced T-zone, fewer midday shine issues and a lower chance of clogged pores
- Skin Protecting: It supports the skin’s own defense system, reinforcing the barrier so it can better resist pollution, irritants and moisture loss. This protective action can leave skin feeling stronger and looking smoother over time
Who Can Use Sh-Oligopeptide-71
Thanks to its lightweight, oil-balancing profile Sh-Oligopeptide-71 is most appreciated by people with oily or combination skin, yet it is generally suitable for normal or slightly dry types as well when paired with a nourishing base. Extremely dry or compromised skin may find it too mattifying if used alone, so layering it under a richer cream is advised in that case.
The peptide is produced entirely through synthetic laboratory processes with no animal-derived inputs, making it a vegan- and vegetarian-friendly choice.
No specific warnings exist for pregnant or breastfeeding women, but out of an abundance of caution anyone who is expecting or nursing should ask a qualified healthcare provider before adding new skincare products that contain Sh-Oligopeptide-71. This information is educational, not medical advice.
The ingredient is not known to increase photosensitivity, so it does not heighten the risk of sunburn on its own. Regular sun protection is still recommended as part of any daily routine.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Oligopeptide-71 vary from person to person. The points below outline potential side effects that have been observed or theorised, though most users experience none of these when the ingredient is formulated and applied as intended.
- Mild stinging or tingling shortly after application, usually transient
- Temporary dryness or tightness, especially if used in a very lightweight formula on already dry skin
- Redness or irritation in individuals with highly sensitive skin
- Rare allergic reaction presenting as itching, swelling or small hives
- Rebound oiliness if the product is overused, leading sebaceous glands to compensate
- Enhanced drying effect when layered with strong retinoids or high-percentage exfoliating acids
If any persistent discomfort or visible reaction occurs stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0/5. Sh-Oligopeptide-71 is a water-soluble micro-peptide that contains no heavy oils, waxes or pore-clogging fatty acids, so it sits lightly on skin and rinses away cleanly. Because it influences sebum output rather than adding extra lipids it poses virtually no risk of blocking follicles.
That makes the ingredient well suited to people who are prone to acne or frequent breakouts.
Keep in mind that a product’s overall comedogenic potential also depends on the other ingredients in the formula plus individual skin chemistry.
Summary
Sh-Oligopeptide-71 is a lab-crafted fragment of dynorphin A that helps curb excess oil and bolster the skin barrier. By sending calming signals to sebaceous glands it encourages balanced sebum levels while its peptide structure supports proteins that reinforce the surface shield, helping skin stay resilient against pollution, dehydration and everyday stress.
The peptide has gained a modest but growing following in mattifying serums, anti-blemish creams and lightweight primers. It is less talked about than big-name actives like niacinamide yet formulators who target oily or combination skin appreciate its precise sebum-tuning action.
Overall safety is rated high thanks to its purity and low irritation profile. Side effects are uncommon and usually mild. As with any new skincare ingredient it is wise to perform a patch test when starting a product that contains Sh-Oligopeptide-71 just to be on the safe side.