What Is Sh-Oligopeptide-74?
Sh-Oligopeptide-74 is a lab made fragment of the human growth protein somatropin. The fragment holds 16 of the standard amino acids in the same order found in the natural protein, letting it communicate with skin in a familiar way. Chemists build the peptide through solid phase peptide synthesis, adding one amino acid at a time until the full chain is complete, then purifying it for cosmetic use.
Peptide research gained speed in the early 2000s when brands noticed that short chains of amino acids could signal skin to look fresher. Sh-Oligopeptide-74 joined formulas a few years later as labs searched for fragments that mimic growth factors without using human or animal extracts. Because it is entirely synthetic it avoids ethical and safety issues linked to biological sourcing.
You will usually spot Sh-Oligopeptide-74 in anti aging serums, firming creams, sheet masks, eye gels, post-procedure calming products and high performance moisturizers where brands want to support smoother looking skin and a plump feel.
Sh-Oligopeptide-74’s Cosmetic Benefits/Uses
In topical products Sh-Oligopeptide-74 is classed as a skin conditioning ingredient, meaning it helps the surface feel softer and look healthier. By acting like a mini messenger it encourages the skin’s own renewal signals, which can lead to a more even tone and a supple texture. It also pairs well with hydrators like glycerin or hyaluronic acid, boosting the overall comfort of a formula without adding weight.
Who Can Use Sh-Oligopeptide-74Most skin types, including dry, balanced, combination and oily, can use Sh-Oligopeptide-74 because the peptide itself is lightweight and non greasy. Sensitive skin usually tolerates it as well since it is fragrance free and made to copy a piece of a natural body protein. People with very reactive or broken skin should still choose a formula that is simple and free of added irritants.
The ingredient is made entirely in the lab without any animal parts or by-products so it suits both vegetarians and vegans.
No data links Sh-Oligopeptide-74 to problems during pregnancy or while breastfeeding. That said this is not medical advice and anyone who is pregnant or nursing should show their skincare routine to a health professional first to be safe.
The peptide does not make skin more sensitive to sunlight and it is fine to use year round. Standard daily sunscreen habits are still important for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Oligopeptide-74 differ from person to person. The points below outline potential effects yet most users will not notice any issues when the ingredient is used at normal cosmetic levels.
- Mild redness or warmth
- Temporary stinging on very compromised skin
- Itchiness or rash in those allergic to one of the formula’s other ingredients
- Breakouts if the surrounding product is heavy or pore clogging
If any unwanted reaction appears stop using the product and consult a healthcare professional if symptoms do not settle quickly.
Comedogenic Rating
Rating: 0/5. Sh-Oligopeptide-74 is a tiny water-soluble peptide that does not leave an oily film or block pores. It sits in the watery part of a formula and rinses away with normal cleansing, so it has virtually no chance of trapping dead skin or sebum. For this reason it is considered safe for people who are prone to acne or breakouts. Only the overall product texture and other ingredients will affect pore clogging risk.
Summary
Sh-Oligopeptide-74 is a lab made 16-amino-acid fragment that conditions skin by acting as a mini messenger. It supports smoother texture, a plump feel and a healthier looking tone while working well alongside hydrators. The peptide is still a niche player compared with classics like hyaluronic acid yet it is gaining attention in high end serums and masks that target firmness and recovery.
Current data shows the ingredient is gentle, non-comedogenic and suitable for most skin types including sensitive. As with any new skincare step it is wise to patch test first to check personal tolerance, especially if your skin is reactive.