Sh-Oligopeptide-89 Sp: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sh-Oligopeptide-89 Sp?

Sh-Oligopeptide-89 Sp is a lab-made fragment of a natural human protein called Keratin-associated protein 1-1. While the full parent protein is 177 amino acids long, this ingredient focuses on a precise 12-amino-acid stretch that scientists identified as helpful for caring for hair. Because it is produced synthetically, no animal or plant harvesting is required. Chemists usually build the peptide step by step through solid-phase peptide synthesis, a method that links each amino acid in the right order, then purifies and dries the finished powder.

The idea of using short, skin- and hair-friendly peptides took off in the early 2000s when brands started looking for targeted ingredients that could copy the body’s own building blocks. Sh-Oligopeptide-89 Sp followed that trend, entering the market as a new way to boost the feel and appearance of hair without heavy oils or silicones.

After production, the peptide is blended into water-based solutions, often alongside humectants and mild preservatives, to keep it stable and easy to add during manufacturing. You will most often see it in rinse-off and leave-in hair conditioners, nourishing hair masks, lightweight serums and styling creams aimed at smoothing, strengthening and adding softness.

Sh-Oligopeptide-89 Sp’s Cosmetic Benefits/Uses

This ingredient is valued for one main purpose in beauty formulas.

Hair Conditioning: Sh-Oligopeptide-89 Sp lines up along the hair shaft, helping to fill in weak spots on the cuticle surface. By doing so it can leave strands feeling smoother, reduce snagging during combing and give a soft, healthy touch without weighing hair down.

Who Can Use Sh-Oligopeptide-89 Sp

This peptide suits virtually every scalp type including normal, dry, oily or sensitive. Because it is lightweight and free from pore clogging oils it does not leave a greasy feel even on fine hair or an easily irritated scalp. No specific scalp type is known to react badly to it.

Sh-Oligopeptide-89 Sp is created entirely in the lab without animal by-products so it is compatible with vegan and vegetarian lifestyles.

Topical use during pregnancy or while breastfeeding is generally considered low risk since the molecule is too large to penetrate deeply, but this is not medical advice. Expectant or nursing parents should still discuss any new cosmetic product with their healthcare provider to be safe.

The ingredient does not make skin or scalp more sensitive to sunlight and no special sun-protection steps are required beyond regular daily SPF habits.

Potential Side Effects/Adverse Reactions

Responses to Sh-Oligopeptide-89 Sp vary from person to person. The points below outline possible issues yet most people will not experience them when using a correctly formulated product.

  • Mild scalp irritation such as tingling or redness, especially on very sensitive skin
  • Allergic contact dermatitis presenting as itching, rash or small bumps
  • Eye stinging if the product accidentally drips into the eyes during application
  • Interaction with existing scalp conditions like eczema or psoriasis which may become temporarily aggravated

If any unwanted reaction occurs stop using the product immediately and seek medical advice if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 / 5

Sh-Oligopeptide-89 Sp is a water-soluble peptide with no oily or waxy parts so it does not sit in pores or form a film that could trap debris. This structure makes it practically impossible for the ingredient to block follicles which is why it earns the lowest score on the comedogenic scale.

Because of this, it is considered safe for people who are prone to acne or frequent breakouts.

The only caveat is that the final product formula matters. If the peptide is blended into a very rich cream packed with heavy emollients the overall product could still clog pores even though the peptide itself does not.

Summary

Sh-Oligopeptide-89 Sp is a lab crafted 12-amino-acid fragment of a natural hair protein. Its main job is hair conditioning. The tiny peptide aligns along the damaged spots of the cuticle helping to smooth rough edges, lessen snagging and add a soft touch without weight.

While not yet a household name it is gaining traction in niche hair masks, leave-ins and styling serums that cater to consumers looking for lightweight science-backed care instead of heavy oils.

Safety data so far point to a very low risk of irritation, allergy or pore clogging. As with any new cosmetic, do a small patch test when you first try a product that lists Sh-Oligopeptide-89 Sp just to be on the safe side.

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