Sh-Oligopeptide-95 Sp: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sh-Oligopeptide-95 Sp?

Sh-Oligopeptide-95 Sp is a lab-crafted peptide that draws on pieces of telomerase-associated protein 2, a component linked to the enzyme that protects DNA ends. Chemically, it is a short chain of amino acids designed to stay stable in water-based formulas. It was first explored by biotech researchers looking for gentle ways to guard skin from everyday stress. When peptide technology proved useful for smoothing lines and boosting skin repair, this specific fragment was refined for cosmetic use.

The production process starts with bio-engineering. Scientists program harmless bacterial or yeast cultures to produce the exact amino acid sequence, then purify the peptide through filtration and freeze-drying. The result is a fine, white powder that dissolves easily into creams, serums and masks without altering their texture.

You will most often spot Sh-Oligopeptide-95 Sp in anti-aging serums, revitalizing sheet masks, daily moisturizers aimed at dull skin and targeted eye treatments. Because it is water-soluble and works well at low doses, formulators can add it to lightweight gels or richer creams alike.

Sh-Oligopeptide-95 Sp’s Cosmetic Benefits/Uses

In skin care formulas Sh-Oligopeptide-95 Sp is valued for one main role.

Antioxidant: The peptide helps neutralize free radicals created by UV light, pollution and normal metabolism. By reducing this oxidative stress, it supports a brighter tone, keeps collagen from breaking down as fast and pairs well with sunscreens or vitamin C to reinforce overall skin defense.

Who Can Use Sh-Oligopeptide-95 Sp

Thanks to its lightweight water-based nature Sh-Oligopeptide-95 Sp suits most skin types including oily, dry, combination and even sensitive skin. It offers antioxidant support without a greasy feel or clogging risk. Those with extremely reactive or broken skin barriers may want to introduce it slowly because any new peptide could trigger a brief adjustment period.

The peptide is produced by fermenting yeast or bacteria then purifying the resulting amino acid chain, so no animal materials are involved. This makes it appropriate for vegans and vegetarians.

Current safety data show no specific concerns for topical use during pregnancy or breastfeeding. That said this information is not medical advice and anyone who is pregnant or nursing should discuss new skincare products with a healthcare professional just to be safe.

Sh-Oligopeptide-95 Sp does not cause photosensitivity. In fact its antioxidant activity can add a layer of protection when paired with sunscreen. It also plays well with most common ingredients such as niacinamide and hyaluronic acid.

Potential Side Effects/Adverse Reactions

Reactions to topical Sh-Oligopeptide-95 Sp vary from person to person. The following points outline potential side effects yet most users experience none of these issues when the peptide is formulated correctly and used as directed.

  • Mild redness or warmth right after application
  • Transient stinging around the eye area if the formula is highly concentrated
  • Allergic contact dermatitis in individuals sensitive to peptides or preservation agents used alongside the ingredient
  • Increased irritation when layered immediately after very acidic products that destabilize the peptide

If any persistent discomfort swelling or rash occurs stop using the product and consult a qualified healthcare provider.

Comedogenic Rating

Rating: 0/5. Sh-Oligopeptide-95 Sp is fully water soluble and contains no oily or waxy components that could block pores. It sits on the skin surface, provides antioxidant action then rinses or wears away without leaving residue that traps sebum or debris.

Because of this zero rating it is generally suitable for people who are prone to acne or frequent breakouts.

Keep in mind the overall formula matters. Heavy creams, rich plant butters or occlusive silicones mixed with the peptide can still cause congestion even though the peptide itself does not.

Summary

Sh-Oligopeptide-95 Sp is a lab engineered antioxidant peptide that helps mop up free radicals, slow collagen breakdown and support a brighter steadier complexion. It achieves these results by donating electrons to unstable molecules, effectively stopping the chain reactions that lead to dull tone and fine lines.

The ingredient is still a niche player compared with staples like vitamin C or niacinamide, yet its ease of formulation and gentle profile are winning it a spot in newer serums, masks and eye creams.

Current data show a strong safety margin with very low irritation risk. Even so skin can be unpredictable, so it is wise to patch test any new product that features this peptide before making it part of a daily routine.

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