What Is Sh-Oligopeptide-97 Sp?
Sh-Oligopeptide-97 Sp is the cosmetic name for thymosin alpha-1, a short chain of amino acids originally isolated from the thymus gland. Today it is produced in the lab, most often through solid-phase peptide synthesis or recombinant DNA technology, which allows precise control over purity and consistency. Interest in thymosin alpha-1 began in medical research during the 1970s but formulators soon noticed that its structure could support healthier looking hair. As a result peptide specialists adapted the molecule for topical use, giving it the INCI name Sh-Oligopeptide-97 Sp.
Once purified the peptide is blended into water-based concentrates, then added to finished products during the cool-down phase to protect its delicate structure. You will spot it in shampoos, rinse-off conditioners, leave-in sprays, scalp serums, hair masks and targeted anti-breakage treatments where brands look for lightweight yet potent actives.
Sh-Oligopeptide-97 Sp’s Cosmetic Benefits/Uses
In beauty formulas Sh-Oligopeptide-97 Sp serves one clear purpose.
Hair conditioning: The peptide helps smooth the hair cuticle, improving softness and manageability while reducing the rough feel that comes from mechanical or chemical stress. By supporting a healthier looking surface it can also enhance shine and make detangling easier, giving the overall appearance of stronger, well-cared-for strands.
Who Can Use Sh-Oligopeptide-97 Sp
Because it is a lightweight peptide, Sh-Oligopeptide-97 Sp is generally suitable for all scalp and hair types, including oily, dry, color treated or chemically processed strands. Its water-based nature means it will not weigh down fine hair and it does not deposit heavy residues that could trouble oily scalps. Those with very sensitive or allergy-prone skin should still read full ingredient lists to make sure there are no added fragrances or preservatives that personally bother them.
The peptide is produced through laboratory synthesis, so no animal-derived materials are used at any step. This makes it a friendly option for vegans and vegetarians who wish to avoid ingredients sourced from animals.
Current data shows no special concerns for people who are pregnant or breastfeeding when Sh-Oligopeptide-97 Sp is used topically in rinse-off or leave-on hair products. That said this information is not medical advice and anyone expecting or nursing should run any new personal care product past a healthcare professional to be on the safe side.
Sh-Oligopeptide-97 Sp is not known to cause photosensitivity and does not interfere with sun protection, so normal daylight exposure is fine after use.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Sh-Oligopeptide-97 Sp can vary from person to person. The points below outline potential issues, yet they are unlikely to be the typical user experience when the ingredient is formulated and used as intended.
- Mild scalp redness or tingling: Usually short lived and linked to a fresh increase in microcirculation
- Itching or dryness: May occur if the formula contains other sensitising additives like high alcohol levels
- Allergic contact dermatitis: Rare but possible in individuals with a specific peptide allergy or compromised skin barrier
- Eye irritation: Only if the product accidentally drips into the eyes during application or rinsing
If any troubling reaction develops discontinue use and seek advice from a pharmacist or medical professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Oligopeptide-97 Sp is a tiny water-soluble peptide that rinses clean and does not leave an oily film so it has virtually no pore-clogging potential. It carries no fats or waxes that could build up on skin or scalp.
Because of this low risk it is considered suitable for people who are prone to acne or breakouts.
Keep in mind that the overall formula counts. If the product also contains heavy oils or butters those other ingredients, not the peptide itself, might be the real trigger for congestion.
Summary
Sh-Oligopeptide-97 Sp is a lab-made version of thymosin alpha-1 used in haircare to smooth the cuticle, boost softness, improve shine and make detangling easier. It works by binding lightly to damaged areas of the hair shaft, helping the surface lie flatter which reduces friction and enhances light reflection.
Although effective it is still a niche ingredient, mostly found in premium scalp serums and targeted conditioners rather than every shampoo on the shelf.
Safety data shows it is well tolerated for topical use with a very low risk of irritation or clogged pores. As with any new cosmetic it is smart to run a quick patch test first just to be sure your skin agrees with the full formula.