What Is Sh-Polypeptide-113?
Sh-Polypeptide-113 is a lab made version of a natural human protein called lactotransferrin. Scientists copy the gene that tells the body how to build lactotransferrin, slip that genetic code into a harmless strain of E. coli, then let the bacteria grow in large tanks. As the bacteria multiply they produce the peptide, which is later purified, checked for safety, and dried into a powder that can be mixed into skin care formulas. Chemically, it is a single chain of up to 710 amino acids, sometimes linked by tiny sulfur bridges or decorated with simple sugar groups. Since it mirrors a human protein the skin usually recognizes it and welcomes its support.
The beauty world first noticed lactotransferrin for its role in keeping skin calm and protected, so brands began using the recombinant version to get the same benefits without relying on animal or human sources. Today you are most likely to find Sh-Polypeptide-113 in age defense serums, soothing moisturizers, sheet masks, eye creams, and leave-on treatments aimed at strengthening the skin barrier.
Sh-Polypeptide-113’s Cosmetic Benefits/Uses
This ingredient earns its place in formulas by offering two main advantages for the skin.
- Skin conditioning – helps the outer layers stay hydrated and feel soft which can improve overall texture and give a smoother appearance
- Skin protecting – supports the skin’s natural barrier so it can better defend itself against everyday stress like pollution UV light and harsh weather
Who Can Use Sh-Polypeptide-113
Because it is modeled after a protein naturally found in the body Sh-Polypeptide-113 is gentle enough for most skin types. Dry skin appreciates its conditioning effect while sensitive or compromised skin often benefits from the extra barrier support. Oily and acne prone skin can also use it since it is lightweight and non occlusive. There are no known reasons for people with darker skin tones or rosacea to avoid it.
The peptide is produced by fermenting a plant based growth medium with genetically modified E. coli so no animal derived material is used. This makes products containing Sh-Polypeptide-113 suitable for vegans and vegetarians.
No data suggests that the ingredient poses a special risk to pregnant or breastfeeding women when applied topically at cosmetic levels. Still this is not medical advice and anyone who is pregnant or nursing should check with a healthcare professional before adding new skincare products.
Sh-Polypeptide-113 does not increase photosensitivity so daytime use is fine. It is compatible with most common skincare actives including vitamins C and E niacinamide and mild exfoliating acids.
Potential Side Effects/Adverse Reactions
Everyone’s skin is different so the following issues may occur in rare cases. These are only potential reactions and most users should experience none of them if the product has been properly formulated.
- Mild redness or flushing
- Itching or a tingling sensation shortly after application
- Localized swelling or hives indicating an allergy to the peptide or another formula component
- Contact dermatitis if combined with an aggressive exfoliant or irritant in the same routine
- Stinging on broken or compromised skin
If any of these effects appear stop using the product and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0/5. Sh-Polypeptide-113 is a large water-soluble peptide that sits on the skin surface and does not mix with skin oils, so it is extremely unlikely to block pores. Because it carries no oily or waxy components the molecule simply cannot form the kind of plug that leads to blackheads or pimples. This makes it well suited to acne-prone or breakout-prone skin. No published reports link the peptide itself to comedogenic reactions, although a finished product could still clog pores if other heavier ingredients are present.
Summary
Sh-Polypeptide-113 conditions and protects the skin by mimicking lactotransferrin, a naturally occurring protein that helps keep the outer layer hydrated, soothed and resilient. It binds moisture, supports the barrier and offers a mild shield against environmental stress. While not a headline ingredient like retinol or vitamin C, it is gaining quiet popularity in premium serums and masks aimed at sensitive or barrier-compromised skin.
Current data shows the peptide is well tolerated with a very low risk of irritation or pore clogging when used at cosmetic levels. Still, everyone’s skin is unique so it is smart to patch test any new product that contains Sh-Polypeptide-113 before applying it to the entire face.