What Is Sh-Polypeptide-132?
Sh-Polypeptide-132 is a lab made copy of part of the human protein Laminin Gamma-2. Scientists recreate the gene that tells cells how to make this protein, put that gene into helpful strains of E. coli bacteria, then let the bacteria grow in large tanks. The bacteria read the gene and build the peptide chain one amino acid at a time. Afterward the mixture is filtered and purified so only the peptide remains. The result is a single-chain protein that can be up to 1193 amino acids long and may include natural links like disulfide bonds or sugar groups.
The idea of using human-identical peptides in skin care took off in the early 2000s when brands began looking for gentler ways to signal skin to renew itself. Because Sh-Polypeptide-132 matches a piece of a natural skin protein it tends to be well accepted by the skin barrier. Today you will most often spot it in leave-on products such as serums, anti-aging creams, masks, concentrated ampoules and post-procedure soothing gels. It is usually added at low percentages alongside hydrators and antioxidants to round out a skin repairing formula.
Sh-Polypeptide-132’s Cosmetic Benefits/Uses
This ingredient is prized mainly for its skin conditioning property. By acting as a supportive protein fragment it helps soften skin, improves the way moisture is held in the outer layers and leaves the surface feeling smoother. Regular use can make the complexion look more even and refreshed which is why formulators reach for it in products aimed at tired or mature skin.
Who Can Use Sh-Polypeptide-132
Because this peptide is non irritating and biomimetic it suits virtually all skin types including dry, normal, combination, oily and sensitive skin. Those with very reactive or allergy-prone complexions usually tolerate it well since it lacks common fragrance or preservative triggers. There are no known reasons to avoid it for any specific skin type, though people experiencing an active infection or open lesions should wait until the skin has healed before applying any cosmetic product.
Sh-Polypeptide-132 is produced through bacterial fermentation with no animal-derived inputs, making it appropriate for vegans and vegetarians. The finished material is identical to a human peptide yet sourced entirely from microbes.
Pregnant or breastfeeding individuals are not known to face special risk when using products containing this ingredient. Research on topical peptides shows low systemic absorption, nevertheless this is not medical advice and anyone expecting or nursing should run any skincare choices past a qualified healthcare provider to be safe.
The peptide does not increase photosensitivity, so it can be used morning or night without raising the chance of sunburn. Standard daytime sun protection is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to any skincare ingredient can differ from one person to the next. The points below outline potential side effects of topical Sh-Polypeptide-132 though most users will not experience them when the ingredient is properly formulated and applied.
- Transient redness or warmth
- Mild itching or tingling
- Localized rash or hives due to rare allergic sensitivity
- Contact dermatitis if combined with other irritating actives in the same formula
If you notice any unexpected or worsening reaction stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
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Sh-Polypeptide-132 is a large, water-soluble peptide that stays on the skin surface and is not oily or waxy so it does not block pores. Its hydrophilic nature means it mixes with the watery phase of a formula rather than the oil phase that can create congestion. Because of this the ingredient itself is considered non-comedogenic.
Suitable for acne-prone or breakout-prone skin.
Keep in mind that the final product’s comedogenicity depends on the full formula. If the peptide is blended with heavy butters or thick occlusives the risk of clogged pores comes from those ingredients, not the peptide.
Summary
Sh-Polypeptide-132 is a lab made fragment of the human Laminin Gamma-2 protein that conditions skin by boosting surface hydration, supporting the feel of a healthy barrier and leaving skin smoother and more even. It works by mimicking a natural extracellular matrix component so skin cells readily accept its signals without irritation.
While not as widely recognized as collagen fragments or copper peptides it is showing up in more targeted serums and post-procedure treatments as brands look for gentle repair boosters.
Safety studies and real-world use point to a very low risk of irritation or sensitization, and its non-comedogenic profile suits every skin type. Still it is smart to patch test any new product to make sure your individual skin agrees with the full formula.