What Is Sh-Polypeptide-26?
Sh-Polypeptide-26 is a lab-made version of a naturally occurring human protein known as FMS Related Tyrosine Kinase Ligand. Scientists start by designing a short piece of DNA that matches the human gene, then place it inside a harmless strain of E. coli. As the bacteria grow in a fermentation tank they churn out the peptide, which can include up to 235 amino acids along with stabilizing disulfide bonds or small sugar groups. After fermentation the peptide is purified, checked for quality, and blended into cosmetic formulas.
This ingredient reached the beauty world during the rise of biotech peptides in the early 2000s, when brands began looking for precise lab-crafted actives that could mimic signals found in our own skin. Because it can be produced in large batches without animal sources, it quickly became attractive to companies focused on advanced yet cruelty-free skincare.
You will most often see Sh-Polypeptide-26 in anti-aging serums, firming creams, rich moisturizers, sheet masks, eye treatments, and targeted booster drops. Its main role is to condition the skin, so formulators add it to products aimed at smoothing texture, enhancing hydration, and supporting a fresher appearance.
Sh-Polypeptide-26’s Cosmetic Benefits/Uses
Sh-Polypeptide-26 is valued mainly for one key function that can elevate everyday skincare.
As a skin-conditioning agent it helps skin feel softer, look smoother, and maintain healthy moisture levels. By supporting the skin’s surface proteins it can improve overall suppleness, reduce the appearance of rough patches, and give a more vibrant finish to the complexion.
Who Can Use Sh-Polypeptide-26
Sh-Polypeptide-26 is generally well suited for all skin types including dry, normal, combination, oily and sensitive skin because it focuses on conditioning rather than aggressive exfoliation or resurfacing. It is water-soluble and lightweight so it rarely leaves a greasy film that might bother oily or acne-prone complexions while its gentle nature makes it comfortable for easily irritated skin.
The peptide is created through bacterial fermentation with no animal derived materials, making it appropriate for both vegans and vegetarians.
Current research shows no specific risks for pregnant or breastfeeding women when this ingredient is applied topically. That said this is not medical advice and anyone who is expecting or nursing should have a quick chat with their healthcare provider before adding new skincare products, just to be safe.
Sh-Polypeptide-26 does not increase photosensitivity so there is no extra sun-related caution beyond your usual daily SPF.
Potential Side Effects/Adverse Reactions
Side effects and reactions to the topical application of Sh-Polypeptide-26 can vary from person to person. The list below covers potential issues yet most users will not experience any negative effects when the ingredient is formulated correctly.
- Mild redness or flushing shortly after application
- Transient stinging or warmth on very sensitive skin
- Itchiness or dryness if paired with other strong actives
- Allergic contact dermatitis in individuals sensitive to peptides or fermentation residues
- Swelling or hive-like bumps in rare cases of true allergy
If you notice any persistent discomfort or visible reaction stop using the product and seek advice from a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 out of 5. Sh-Polypeptide-26 is a large water-soluble peptide that sits on the surface of the skin and rinses away easily, so it has no tendency to clog pores. It contains no oils or waxes that could trap sebum and bacteria, making it a safe pick for acne-prone or breakout-prone skin.
Do keep in mind that the overall formula can change things. If the peptide is blended into a heavy cream packed with rich plant butters the product itself could still feel pore-clogging even though the peptide is not the culprit.
Summary
Sh-Polypeptide-26 is a lab-crafted peptide used mainly for skin conditioning. By mimicking signals found naturally in human skin it helps smooth texture support moisture levels and leave the complexion looking fresh and supple.
It shows up mostly in higher-end serums eye creams and masks rather than basic cleansers or toners so you may not see it on every shelf yet brands that focus on biotech actives are starting to feature it more often.
Safety data so far points to a very low risk of irritation or pore blockage and its vegan origin appeals to many shoppers. As with any new skin care ingredient it is smart to do a quick patch test when trying a product that contains Sh-Polypeptide-26 just to make sure your skin stays happy.