What Is Sh-Polypeptide-31?
Sh-Polypeptide-31 is a lab-engineered version of a natural human protein known as Insulin-Like Growth Factor 2. Scientists recreate the exact gene that tells our bodies how to make this protein then insert that gene into harmless E. coli bacteria. As the bacteria grow they produce the peptide, which is later purified and checked for safety. Chemically it is a single-chain protein that can include up to 180 amino acids, sometimes linked by disulfide bonds or carrying small sugar groups called glycosylations. Because it mirrors a human protein the body can recognize it, making it gentle on skin.
The ingredient first drew attention in medical research where growth factors were studied for wound care and tissue repair. Seeing its ability to signal healthy skin renewal, cosmetic chemists adapted it for topical use in the early 2000s. Modern fermentation methods now allow large-scale production that meets cosmetic grade standards.
Brands typically add Sh-Polypeptide-31 to products aimed at improving skin texture and firmness. You will often spot it in anti-aging serums, sheet masks, concentrated ampoules, lightweight moisturizers and specialty night creams where it supports overall skin conditioning.
Sh-Polypeptide-31’s Cosmetic Benefits/Uses
In skin care formulas Sh-Polypeptide-31 serves one main role that drives several visible benefits.
Skin conditioning: This peptide supports the skin’s natural renewal cycle so the surface looks smoother and more even. By encouraging healthy cell turnover it can help soften the look of fine lines and improve overall tone. Its conditioning action also boosts skin comfort which can make the complexion feel supple and well cared for.
Who Can Use Sh-Polypeptide-31
Because it mirrors a naturally occurring human protein Sh-Polypeptide-31 is generally well tolerated by all major skin types including dry, oily, combination and sensitive. People with an already inflamed or severely compromised skin barrier should proceed cautiously, as any active ingredient can feel irritating on skin that is already stressed.
The peptide is produced through fermentation in bacteria, with no animal tissue involved, so it aligns with vegan and vegetarian lifestyles provided the final formula is free of other animal derived additives such as beeswax or collagen.
There is no specific evidence showing harm to pregnant or breastfeeding women when the peptide is used on skin, but safety data is limited. This information is not medical advice and anyone who is pregnant or nursing should ask a qualified healthcare professional before adding new products, just to be safe.
Sh-Polypeptide-31 is not known to cause photosensitivity and does not make skin more vulnerable to sunburn. Standard daytime sun protection habits remain important for overall skin health.
The ingredient pairs well with moisturizers, antioxidants and gentle exfoliants, though very strong actives like high-percentage acids or prescription retinoids might increase the chance of irritation if layered without adequate spacing.
Potential Side Effects/Adverse Reactions
Individual reactions to topical Sh-Polypeptide-31 can vary. The following points outline potential side effects, but most users will not experience them when the ingredient is included at cosmetic levels in a well formulated product.
- Mild redness or irritation especially on very sensitive or broken skin
- Temporary tingling or warmth that fades within minutes of application
- Rare allergic response such as itching, rash or localized swelling
- Breakouts if the overall product texture is too heavy for acne-prone skin
- Over stimulation when combined with potent exfoliating acids or strong retinoids in the same routine
If any of these effects occur stop using the product and consult a healthcare professional if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-31 is a large water-soluble protein molecule that does not contain oily or waxy components known to clog pores. It sits on the surface, delivers its conditioning signals, then rinses or wears away without mixing into sebum. Formulas that feature it typically rely on light, aqueous bases which further lowers any clogging risk.
This makes the ingredient suitable for people who are prone to acne or frequent breakouts.
Keep in mind overall pore safety depends on the full product recipe. Rich creams that use heavy butters or occlusive silicones could still trigger congestion even if the peptide itself is non-comedogenic.
Summary
Sh-Polypeptide-31 is a lab-crafted match to the human growth factor IGF-2 that assists skin renewal and conditioning. By signaling healthy cell turnover it helps smooth texture, soften fine lines and support a comfortable, balanced complexion.
While not yet a household name, the peptide is gaining traction in targeted serums, ampoules and high-performance moisturizers as brands look for gentle actives that deliver visible results.
Safety data so far shows a low risk for irritation or breakouts and no links to photosensitivity. As with any new skincare ingredient it is wise to patch test a small area first and discontinue use if redness, itching or other discomfort appears.