What Is Sh-Polypeptide-37?
Sh-Polypeptide-37 is a lab made version of a tiny protein that naturally occurs in the body. Scientists create it by inserting a synthesized human gene, identical to the one that makes Interleukin 15, into harmless E. coli bacteria. The bacteria then act like mini factories, producing the peptide during a controlled fermentation process. Afterward the peptide is carefully purified so it contains the correct sequence of up to 162 amino acids, sometimes linked by disulfide bonds or carrying small sugar groups called glycosylations.
The idea of borrowing the body’s own building blocks for skincare gained traction in the early 2000s as biotechnology advanced. Brands soon realized that peptides like Sh-Polypeptide-37 could be produced consistently at scale and added to topical formulas to mimic some of the skin’s natural signaling. Today you will find Sh-Polypeptide-37 in a range of products such as lightweight serums, anti aging creams, sheet masks and targeted treatment ampoules where its main job is to keep skin feeling smooth and resilient.
Sh-Polypeptide-37’s Cosmetic Benefits/Uses
In cosmetic formulas Sh-Polypeptide-37 serves one clear purpose that delivers noticeable skin improvements.
As a skin conditioning agent, Sh-Polypeptide-37 helps maintain a soft hydrated surface and supports a healthy skin barrier. Regular use can leave skin looking supple and refreshed which is why formulators like to include it in products designed for daily moisture and overall skin revitalization.
Who Can Use Sh-Polypeptide-37
Sh-Polypeptide-37 is gentle enough for most skin types including dry, normal, combination and oily skin. Because it focuses on conditioning rather than exfoliation or oil control it rarely triggers excess dryness or shine, making it a versatile option for everyday routines. Users with very sensitive or highly reactive skin may still wish to introduce it slowly since any new ingredient has a small chance of causing irritation.
The peptide is made through a fermentation process that does not involve animal-derived materials so it is considered suitable for vegetarians and vegans.
Current data shows no specific risk for pregnant or breastfeeding women when Sh-Polypeptide-37 is used topically in cosmetic concentrations. This information is not medical advice and anyone who is expecting or nursing should clear any skincare product with a qualified healthcare provider before use to stay on the safe side.
Sh-Polypeptide-37 does not make skin more sensitive to sunlight so it is not considered a photosensitizer. Regular daytime sun protection is still recommended as part of a healthy skincare routine.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Polypeptide-37 can vary from person to person. The points below outline potential reactions although most users will not experience them when the ingredient is included at the levels normally found in cosmetics.
- Temporary redness or warmth at the application site
- Mild itching or tingling sensation
- Localized rash or hives in people with peptide sensitivities
- Swelling or puffiness if an allergic reaction occurs
- Watery or irritated eyes if the product migrates too close to the eye area
If you notice any persistent discomfort or signs of an allergic reaction stop using the product and consult a healthcare professional.
Comedogenic Rating
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Sh-Polypeptide-37 is a large water-soluble protein that sits on the surface of the skin rather than seeping into pores where clogging can occur. It contains no heavy oils, waxes or fatty acids that typically raise comedogenic potential so formulators consider it non-comedogenic.
This makes Sh-Polypeptide-37 a safe choice for people who are prone to acne or frequent breakouts.
Since the peptide is usually added at low concentrations and is easily rinsed away during cleansing it is unlikely to build up on the skin over time.
Summary
Sh-Polypeptide-37 is a lab crafted copy of a natural human peptide and its main role in cosmetics is skin conditioning. By resting on the skin surface it helps attract and hold water while supporting the barrier that keeps moisture in and irritants out. The result is skin that feels softer, looks smoother and appears more resilient.
The ingredient enjoyed a surge of interest when biotech peptides first entered the beauty scene in the early 2000s. While it is not as famous as buzzier actives like retinol or vitamin C it still finds a spot in modern serums, creams and sheet masks aimed at gentle hydration and overall skin health.
Current research and real-world use suggest Sh-Polypeptide-37 is very safe for topical application with minimal risk of irritation. As with any new skincare product it is smart to perform a quick patch test before full use just to ensure your skin gets along with the formula.