What Is Sh-Polypeptide-45?
Sh-Polypeptide-45 is a lab made peptide that mirrors a natural protein known as Granulocyte Macrophage Colony Stimulating Factor. Scientists produce it through controlled fermentation of engineered E. coli bacteria that carry a copy of the human gene for this protein. After the bacteria grow, the peptide is harvested, purified and dried into a stable powder suitable for skincare formulas. Chemically, it is a single chain of up to 144 amino acids that may form disulfide links and can hold small sugar groups, just like its natural counterpart.
The use of bio identical peptides in beauty care took off in the early 2000s when advances in biotechnology made safe large scale production possible. Brands began exploring Sh-Polypeptide-45 because it offered a targeted way to refresh skin feel without the heaviness of oils or waxes. Today you can spot it in lightweight serums, anti aging creams, sheet masks, eye treatments and soothing post procedure gels where a gentle conditioning boost is needed.
Sh-Polypeptide-45’s Cosmetic Benefits/Uses
Formulators choose Sh-Polypeptide-45 mainly for its ability to improve how skin looks and feels.
- Skin Conditioning – helps soften the surface, supports a smooth texture and enhances overall suppleness which can make the complexion appear fresher and more rested
Who Can Use Sh-Polypeptide-45
Because Sh-Polypeptide-45 is water based and free of heavy oils or fragrances it usually agrees with most skin types including dry, normal, combination and oily. Sensitive skin can also benefit as the ingredient is gentle and non stripping. There are no known reasons it would be unsuitable for acne prone or mature skin, though individual formulas may contain other components that could be comedogenic or irritating.
The peptide is produced by fermenting genetically engineered bacteria rather than being taken from animals so it is considered vegan and vegetarian friendly.
Current data suggests topical use is low risk for pregnant or breastfeeding women when used in standard cosmetic amounts. That said this is not medical advice and anyone who is expecting or nursing should show the full product label to a qualified healthcare provider before adding it to a routine just to be safe.
Sh-Polypeptide-45 does not increase photosensitivity so it can be used morning or night without raising sunburn risk. Still, daily sunscreen is always wise for overall skin health. The peptide also plays well with common actives like niacinamide, hyaluronic acid and most plant extracts making it easy to slot into an existing lineup.
Potential Side Effects/Adverse Reactions
Responses to any cosmetic ingredient can differ from person to person. The points below outline possible but uncommon issues users could face when applying Sh-Polypeptide-45 topically. Assuming the final product is formulated and preserved correctly most people will not encounter these problems.
- Mild redness or warmth
- Transient itching or tingling
- Rare allergic contact dermatitis in those sensitive to peptides or trace fermentation residues
- Breakouts if the surrounding formula contains pore clogging oils or waxes
- Stinging when applied to broken or freshly exfoliated skin
If any persistent irritation or other adverse effect occurs stop use immediately and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sh-Polypeptide-45 is a water-soluble peptide that stays on the surface of the skin then rinses or absorbs without leaving an oily film, so it does not block pores. It is used at very low concentrations, is free of fats and heavy waxes and its molecular size keeps it from settling inside follicles.
Because of this, the ingredient is generally considered safe for people prone to acne or breakouts, although the overall formula still matters.
Keep in mind that a product’s other components, such as rich plant butters or certain silicones, can raise the final comedogenic potential even when Sh-Polypeptide-45 itself is zero.
Summary
Sh-Polypeptide-45 is a lab crafted version of a human growth factor that acts mainly as a skin-conditioning agent, leaving the surface softer, smoother and more supple. It delivers this benefit by forming a lightweight, breathable film that helps maintain moisture balance and supports a healthy-looking complexion.
While not the biggest headline grabber in beauty aisles, it appears with steady frequency in targeted serums, eye creams and post-procedure gels where a gentle, non-greasy boost is valued.
Current evidence shows it is well tolerated with a low risk of irritation or pore clogging, making it a safe addition to most skin routines. As with any new cosmetic ingredient, try a small patch test first to check personal compatibility before applying it all over.