What Is Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7?
Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7 is a lab made fusion peptide created by linking together three smaller peptide genes. Scientists build the combined gene in a lab then place it inside harmless E. coli bacteria. The bacteria act like tiny factories, producing long chains of 1 224 amino acids in the exact order needed. After the bacteria finish the job, the peptide is filtered, purified and dried into a fine powder that can be blended into skincare formulas.
The idea of using designer peptides in beauty products began in the early 2000s when researchers found that short chains of amino acids could send helpful signals to skin cells. Over time, labs learned how to stitch different peptide sequences together to get several benefits in one ingredient. Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7 is one of these modern “multi-tasker” peptides and is now showing up in high end serums and creams.
You will most often spot this peptide in anti-aging serums, rich moisturizers, sheet masks, eye creams and leave-on treatments aimed at boosting skin smoothness and overall vitality.
Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7’s Cosmetic Benefits/Uses
This ingredient is labeled as a skin conditioning agent. In a formula it helps skin feel softer, look healthier and maintain a balanced moisture level. By supporting the skin’s surface it can leave the complexion looking more even and refreshed after regular use.
Who Can Use Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7
This peptide is gentle enough for most skin types, including dry, oily, combination and mature skin. Sensitive skin usually tolerates it as well because it is not acidic and does not exfoliate, though very reactive skin should still add new actives slowly. There are no known concerns for acne-prone users since the molecule is lightweight and water soluble, so it will not clog pores.
The ingredient is produced through plant-free fermentation in E. coli, so it contains no animal material. That makes it suitable for vegans and vegetarians, provided the rest of the formula also meets their standards.
No specific warnings exist for pregnant or breastfeeding women, but safety data is limited. This information is not medical advice. Expectant or nursing mothers should show any product they plan to use to their healthcare provider for personalized guidance.
Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7 does not increase photosensitivity, so it will not make skin more prone to sunburn. Daily sunscreen is still recommended as part of a complete routine.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7 vary from person to person. The points below list potential side effects that could occur, though most users experience none of them when the ingredient is formulated and used correctly.
- Mild redness or warmth
- Temporary stinging or tingling at the application site
- Dry or tight feeling if the formula lacks adequate moisturizers
- Itchiness or hives in those with a peptide sensitivity
- Allergic contact dermatitis, though this is rare
If you notice any of these reactions, discontinue use and consult a healthcare professional for further advice.
Comedogenic Rating
Rating: 0/5
Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7 is a large water-soluble peptide that does not contain greasy oils or waxes, so it cannot settle inside pores or solidify on the skin. Because it stays on the surface then rinses or wears away without leaving behind occlusive residue, it earns a solid 0 for comedogenicity.
This means the ingredient is generally suitable for people who are prone to acne or frequent breakouts.
Keep in mind that overall pore-clogging risk still depends on the full formula. Pairing this peptide with heavy butters or thick silicones could raise the comedogenic profile of the finished product.
Summary
Sh-Polypeptide-56 Tripeptide-44 Rh-Polypeptide-7 is a lab-crafted fusion peptide that conditions skin by sending cell-friendly signals, helping the surface stay hydrated, feel smoother and look more even. Its water-binding nature supports the moisture barrier while the peptide sequence encourages a healthier appearance over time.
Although not yet a household name, the ingredient is gaining traction in premium serums and targeted treatments because brands like the idea of a single multitasking peptide layer rather than several separate ones.
Current data shows it is low risk for irritation, non-comedogenic and vegan friendly. Still, as with any new skincare active it is wise to patch test a fresh product first to make sure your individual skin agrees with it.