What Is Sh-Polypeptide-67?
Sh-Polypeptide-67 is a lab engineered version of sirtuin 2, a protein originally identified in human cells that plays a role in protecting them from stress. Scientists replicate its amino acid chain through fermentation or recombinant technology, allowing the final ingredient to be vegan friendly and consistently pure. Interest in sirtuins grew in the early 2000s when researchers linked them to cell longevity. Cosmetic chemists soon explored topical uses, leading to Sh-Polypeptide-67 appearing in skin care by the mid-2010s.
Production starts with a harmless strain of bacteria or yeast that receives the genetic blueprint for sirtuin 2. After the microbes grow in controlled tanks they release the protein, which is then filtered, purified, and stabilized before being dried into a powder for easy formulation.
You will most often see Sh-Polypeptide-67 in high performance serums, anti aging creams, sheet masks, eye treatments, and leave-in hair products that focus on strength and shine.
Sh-Polypeptide-67’s Cosmetic Benefits/Uses
Below are the key ways this peptide supports beauty formulas
- Antioxidant – helps neutralize free radicals created by UV light and pollution which can lead to dull tone and premature wrinkles. By reducing this daily stress the ingredient supports a fresher looking complexion
- Hair conditioning – coats strands with a light film that improves smoothness and manageability while reducing breakage. Users notice softer touch and enhanced shine
- Skin conditioning – boosts moisture retention and supports a more even surface so skin feels supple and looks healthier
Who Can Use Sh-Polypeptide-67
Because this bio-identical peptide is gentle and non-comedogenic it suits most skin types including dry, oily, combination and sensitive. People with very reactive skin usually tolerate it well since it is free of fragrance and common irritants. There are no known concerns for darker skin tones or acne-prone complexions.
The peptide is produced by fermenting bacteria or yeast rather than sourcing from animals so it is appropriate for vegans and vegetarians.
No specific warnings exist for pregnancy or breastfeeding, yet data in these groups is limited. This information is not medical advice and anyone who is pregnant or nursing should show the full ingredient list of any product to their healthcare provider before use just to be safe.
Sh-Polypeptide-67 is not known to make skin more sun-sensitive. Standard daytime sunscreen habits are still recommended to protect overall skin health.
The ingredient can be layered with most actives such as niacinamide, hyaluronic acid and gentle retinoids without issue.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-67 differ between individuals. The following lists possible side effects that could occur even though most users will not encounter them when the product is formulated and applied correctly.
- Mild redness or warmth especially on very sensitive skin right after application
- Temporary itching or stinging that usually fades within minutes
- Allergic rash or hives in the rare case of sensitivity to the peptide or other formula components
- Eye irritation if a leave-on product accidentally gets into the eyes
- Heavy or greasy feel on fine hair when an overly rich leave-in formula is applied in excess
If any uncomfortable reaction develops stop using the product and consult a qualified healthcare professional.
Comedogenic Rating
Rating: 0/5
Sh-Polypeptide-67 is a water soluble peptide that does not leave an occlusive film or add extra oil to the skin so it is regarded as non comedogenic. It is normally used at very low concentrations and easily rinses or absorbs without blocking pores.
Suitable for acne prone or breakout prone skin.
Keep in mind that a finished product’s pore clogging potential also depends on the other ingredients in the formula not just the peptide itself.
Summary
Sh-Polypeptide-67 is a lab made copy of the human protein sirtuin 2 that offers antioxidant protection, supports smoother hydrated skin and improves hair softness and shine. It scavenges free radicals, helps cells handle daily stress and forms a light conditioning layer on skin or hair.
The peptide shows up in select high performance serums and leave in treatments but it is still considered a niche ingredient rather than a household name.
Current research and user reports point to a very low risk of irritation or pore clogging which makes Sh-Polypeptide-67 safe for most people. As with any new cosmetic it is smart to patch test first to make sure your skin agrees with the full formula.