What Is Sh-Polypeptide-75?
Sh-Polypeptide-75 is a lab crafted version of a human protein fragment originally linked to the enzyme Neuropsin, also known as serine protease TADG-14. Through modern bioengineering, scientists copy the exact DNA code that makes this peptide in the body, then place that code into safe starter cells such as yeast or bacterial cultures. These cells act like tiny factories, producing the peptide in controlled tanks. After fermentation the mixture is filtered, purified and gently dried or blended into a water-based solution so it can slot into skincare formulas.
Interest in skin friendly peptides took off in the early 2000s when researchers noticed certain chains of amino acids could signal the skin to behave as if it were younger or under repair. Sh-Polypeptide-75 joined this wave, prized for its ability to condition and defend the skin’s surface. Today you will spot it in lightweight serums, anti aging creams, overnight masks, barrier repair moisturizers and targeted eye treatments where brands want a high tech yet gentle boost.
Sh-Polypeptide-75’s Cosmetic Benefits/Uses
When added to a formula Sh-Polypeptide-75 brings two core perks for the skin
- Skin conditioning – helps smooth texture, support a healthy moisture balance and leave the complexion feeling softer and more resilient
- Skin protecting – forms a breathable micro film that shields the surface from everyday environmental stress, which can help reduce visible signs of fatigue and dryness
Who Can Use Sh-Polypeptide-75
Sh-Polypeptide-75 is gentle enough for nearly all skin types including dry, normal, combination and oily skin. Its lightweight touch and barrier boosting action mean even sensitive or reactive skin often tolerates it well. Those with very compromised or highly inflamed skin should still approach new products carefully since any active can feel irritating when the skin barrier is already stressed.
The peptide is produced through fermentation in plant based starter cultures which makes it suitable for vegans and vegetarians. No animal derived materials are needed at any stage of its manufacture.
Current research offers no red flags for people who are pregnant or breastfeeding. That said this information is not medical advice and anyone who is expecting or nursing should run the full ingredient list of any skincare product past their healthcare provider just to be safe.
Sh-Polypeptide-75 does not increase photosensitivity so it will not make skin more prone to sunburn. Daily sunscreen is still essential for overall skin health but no special photo precautions are required for this peptide.
Potential Side Effects/Adverse Reactions
Reactions to topical Sh-Polypeptide-75 vary from person to person. The points below describe potential side effects that are unlikely for most users, assuming the product is well formulated and used as directed.
- Mild redness or flushing
- Transient stinging on application
- Rare allergic contact dermatitis marked by itching or small bumps
- Interaction with other highly active ingredients leading to temporary irritation if layered too quickly
If you experience persistent discomfort stop using the product and consult a healthcare professional or dermatologist.
Comedogenic Rating
Rating: 0 out of 5
Sh-Polypeptide-75 is a small, water-soluble protein fragment that does not contain heavy oils, waxes or fatty acids known to clog pores. It sits on the skin briefly, delivers its conditioning benefits, then rinses or wears away without leaving a greasy film. Because of this light profile it scores a solid zero on the comedogenic scale.
People who are prone to acne or frequent breakouts can generally use products with Sh-Polypeptide-75 without worrying about extra congestion.
Keep in mind that final formulas matter. If the peptide is blended into a very rich cream thickened with butters or silicones the overall product could still feel heavy on oily skin even though the peptide itself is pore-friendly.
Summary
Sh-Polypeptide-75 works as a skin conditioner and protector. It helps hold moisture and smooth rough spots while forming a light shield that keeps everyday stressors like pollution or dry air from sapping the skin. By copying a natural human peptide it can nudge the surface toward a healthier balance without harsh action.
The ingredient sits in the niche category of bio-engineered peptides. It is not as famous as well marketed actives like retinol or vitamin C yet it appears more often in premium serums and eye treatments aimed at barrier repair. Brands appreciate its gentle nature and techy backstory even if most shoppers have not heard the name.
Safety data so far is reassuring. The peptide is produced in clean lab settings free of animal material, has a very low irritation record and does not raise sun sensitivity. That said every skin is unique so it is wise to patch test a new product containing Sh-Polypeptide-75 before full use just to be certain your skin agrees with the complete formula.