What Is Sh-Polypeptide-76?
Sh-Polypeptide-76 is a lab-engineered peptide that mimics Transforming Growth Factor Beta-2, a protein naturally produced by the body to help keep skin balanced and resilient. Built from up to 414 amino acids, the molecule can include disulfide bonds and small sugar groups that stabilize its structure. Scientists first explored this protein in medical research, then shifted to cosmetic use when advances in peptide synthesis made it possible to copy the exact amino acid sequence in a safe, consistent way.
The ingredient is usually made through modern biotechnology. One common route is solid-phase peptide synthesis, where each amino acid is linked step by step on a resin until the full chain is complete, followed by folding and purification. Another method uses recombinant DNA, where yeast or bacteria are programmed to produce the protein, which is then refined to cosmetic-grade purity.
Thanks to its skin-friendly profile, Sh-Polypeptide-76 appears in a range of leave-on formulas such as anti-aging serums, day and night creams, hydrating masks, eye treatments and soothing post-procedure gels. Brands value it for its ability to care for the skin without adding weight or fragrance, making it suitable for both luxury and mainstream products.
Sh-Polypeptide-76’s Cosmetic Benefits/Uses
In skin care formulas Sh-Polypeptide-76 serves one key purpose that brings several visible payoffs.
Skin conditioning: This peptide supports the skin’s natural renewal process, helping it hold moisture, feel smoother and look more even. By signaling surface cells to behave like younger ones, it can soften the look of fine lines, reduce the appearance of redness and boost overall radiance, making products feel more effective and comfortable on the skin.
Who Can Use Sh-Polypeptide-76
Because this peptide is non greasy and fragrance free it is generally considered suitable for dry, normal, combination, oily and even sensitive skin. Its gentle nature means it rarely triggers stinging or clogged pores, making it a flexible choice for most routines. People with a history of severe protein allergies should proceed with caution since the ingredient is a lab copy of a human protein fragment.
Sh-Polypeptide-76 is produced entirely through laboratory synthesis or fermentation so it contains no animal-derived material. That makes it appropriate for vegans and vegetarians who wish to avoid ingredients sourced from animals.
No published data suggest the peptide poses specific risks during pregnancy or while breastfeeding. Still, skin and hormone shifts can make reactions less predictable, and research on topical peptides in this group is limited. This is not medical advice and anyone who is pregnant or nursing should review all skincare products with a qualified healthcare professional.
The peptide does not make skin more sensitive to sunlight and has no known interference with UV filters, so it can be used morning or night without raising the risk of sunburn. It also plays well with common actives like niacinamide, hyaluronic acid and non-acidic antioxidants.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Polypeptide-76 can vary from one person to another. The issues listed below are simply potential outcomes and are unlikely to affect the typical user when the ingredient is formulated and stored correctly.
- Mild redness or warmth shortly after application
- Temporary itching on highly sensitive skin
- Rare allergic response such as hives or swelling
- Contact dermatitis if used on broken or compromised skin
- Stinging if the product accidentally gets into the eyes
If any uncomfortable reaction occurs stop use right away and seek medical advice if symptoms persist or worsen.
Comedogenic Rating
Rating: 0 out of 5. Sh-Polypeptide-76 is a water-soluble peptide that does not contain heavy oils, waxes or fatty acids known to block pores. Its large molecular size keeps it on the skin surface rather than sinking into sebaceous follicles, so it has virtually no tendency to create or worsen comedones.
Because it scores a 0, the ingredient is considered suitable for acne-prone or breakout-prone skin.
Formulas that pair this peptide with richer emollients could still feel heavy, so anyone worried about clogging should look at the overall product texture, not just the presence of Sh-Polypeptide-76.
Summary
Sh-Polypeptide-76 is a lab-crafted copy of Transforming Growth Factor Beta-2 that conditions skin by encouraging a smoother renewal cycle, improving hydration and supporting an even tone. It delivers these benefits by signaling surface cells to behave in a more balanced way, which can soften fine lines and reduce visible redness.
The peptide is gaining traction in modern serums and creams, though it is not yet as mainstream as retinol or vitamin C. Brands that focus on biotech actives often highlight it as a gentle alternative for users who want results without irritation.
Safety data show a low risk of side effects when the ingredient is formulated and stored properly. Still, skin is personal so it is always wise to patch test a new product containing Sh-Polypeptide-76 before adding it fully into a routine.