What Is Sh-Polypeptide-89?
Sh-Polypeptide-89 is a lab engineered version of the human enzyme hyaluronan synthase 1, the protein that helps our skin naturally produce hyaluronic acid. Scientists identified the part of the enzyme responsible for kick-starting moisture creation and recreated it as a small, stable polypeptide that can be added to skincare formulas. The peptide is produced through biofermentation where safe strains of bacteria are given a genetic template to churn out the desired protein fragment, which is then purified and standardized for cosmetic use.
First explored by pharmaceutical researchers looking into wound repair, the peptide moved into beauty labs once formulators noticed its ability to boost surface hydration and fight oxidative stress. Today it shows up in moisture-rich serums, sheet masks, anti-aging creams, eye treatments and after-sun products that aim to restore a plump, healthy look.
Sh-Polypeptide-89’s Cosmetic Benefits/Uses
Here is how this multitasking peptide supports skin health when applied topically:
- Antioxidant: Helps neutralize free radicals generated by UV exposure and pollution which can otherwise lead to dullness and fine lines
- Humectant: Attracts water to the skin’s surface for immediate hydration that makes the complexion feel soft and look dewy
- Skin Conditioning: Supports a smoother, more supple texture and can enhance the performance of other actives by keeping the skin barrier comfortable
Who Can Use Sh-Polypeptide-89
Because it is water based and lightweight, Sh-Polypeptide-89 is generally well tolerated by dry, normal, combination and oily skin types. Sensitive skin often does well with it too since the peptide is non acidic and free of fragrance, alcohol and known irritants. At this time there are no skin types that are specifically advised to avoid it, although individuals with a history of reacting to fermented ingredients should proceed carefully.
The peptide is produced through bacterial biofermentation so no animal materials are involved, making it suitable for vegans and vegetarians.
Current research shows no link between topical Sh-Polypeptide-89 and hormonal disruption, so products containing it are usually considered low risk for pregnant or breastfeeding women. This is not medical advice and anyone who is expecting or nursing should review new skincare products with a healthcare professional first.
Sh-Polypeptide-89 does not increase photosensitivity and can be used morning or night. It also layers well with common actives such as retinol, vitamin C and exfoliating acids without known conflicts.
Potential Side Effects/Adverse Reactions
Side effects from topical Sh-Polypeptide-89 differ between individuals. The following list covers potential reactions but most users will not experience them when the ingredient is properly formulated and used as directed.
- Temporary redness or mild irritation, especially on freshly exfoliated or compromised skin
- Itching or tingling in extremely sensitive skin
- Rare contact allergy for those sensitive to peptides or biofermentation derived ingredients
If any of these reactions occur discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-89 is a small, water-soluble peptide with no oils, waxes or heavy emollients so it does not linger in pores or create the kind of film that can trap sebum. Studies and supplier data report no pore-clogging potential even in higher concentrations used for serums.
Suitable for acne-prone and breakout-prone skin.
Because formulation always matters, pair it with lightweight carriers if congestion is a concern.
Summary
Sh-Polypeptide-89 acts as an antioxidant that neutralises daily free radical damage, a humectant that draws water to the skin surface and a conditioning agent that keeps the barrier smooth and comfortable. It does this by mimicking a fragment of the natural enzyme that sparks hyaluronic acid production so skin holds onto moisture more effectively.
The peptide is gaining traction in hydrating serums and mask treatments but is still less common than household names like niacinamide or vitamin C. Early adopters prize it for delivering a plump look without heaviness.
Current evidence points to an excellent safety profile with low irritation risk for all skin types. As with any new cosmetic ingredient a quick patch test is wise before adding a full-size product to your routine.