What Is Sh-Polypeptide-93?
Sh-Polypeptide-93 is a lab-crafted version of insulin-like growth factor binding protein 8, often shortened to IBP-8 or IGFBP-8. In simple terms it is a small chain of amino acids designed to mimic a natural protein already found in the body. Its job in skin care is mainly to help the skin feel smoother and look healthier.
The ingredient entered the cosmetic world as researchers searched for gentler options to support skin renewal without the irritation sometimes linked to stronger actives. By copying a protein the skin already knows, scientists found they could deliver noticeable benefits while keeping the risk of reactions low.
Production starts with fermentation. Harmless bacteria or yeast are given genetic instructions to build the peptide, which is then purified and blended into a stable liquid or powder. This controlled process keeps the final material consistent from batch to batch and removes the need for animal sources.
You are most likely to see Sh-Polypeptide-93 in leave-on products such as anti-aging serums, lightweight moisturizers, sheet masks and targeted eye treatments where a silky feel and fast absorption are prized.
Sh-Polypeptide-93’s Cosmetic Benefits/Uses
In skin care formulas Sh-Polypeptide-93 serves a single yet important role: skin conditioning. By binding water to the surface of the skin and supporting its natural proteins, it helps keep the complexion soft supple and well hydrated. Over time this added moisture can lessen the look of fine lines give a plumper appearance and improve overall skin texture.
Who Can Use Sh-Polypeptide-93
Because it is lightweight and purely focused on conditioning, Sh-Polypeptide-93 tends to suit all main skin types including dry, normal, combination, oily and even sensitive skin. Its low molecular weight helps it sink in quickly without leaving a greasy film, which makes it comfortable for acne-prone or congestion-prone complexions.
The peptide is produced through microbial fermentation with no animal-derived inputs so it is appropriate for vegetarians and vegans who wish to avoid animal ingredients.
Current safety data suggests that topical use poses minimal risk during pregnancy or while breastfeeding; however this is not medical advice and anyone who is pregnant or nursing should still clear any new skincare product with a qualified health professional.
Sh-Polypeptide-93 does not make skin more sensitive to sunlight and can be applied morning or night without raising the chance of sunburn. Of course daily sunscreen remains a good idea for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to any cosmetic ingredient can vary from person to person. The points below cover potential side effects of Sh-Polypeptide-93 when used topically; most users will not experience these issues when the ingredient is formulated and applied correctly.
- Mild redness or warmth – usually short-lived as the skin adjusts
- Transient itching or tingling – typically resolves within minutes
- Dry patches – rare and often linked to over-use with strong exfoliants
- Contact dermatitis – very uncommon but possible in those with a specific peptide sensitivity
- Allergic reaction – characterized by swelling or hives that require prompt medical attention
If any of the above reactions occur stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0/5 (non-comedogenic)
Sh-Polypeptide-93 is a water-soluble peptide with no fatty or occlusive components, so it does not block pores or trap oil. Its small molecular size and quick absorption further lower the chance of clogging follicles.
Because of this, the ingredient is generally considered suitable for acne-prone or breakout-prone skin.
Keep in mind that overall formula matters; heavy oils, waxes or rich butters paired with the peptide could still contribute to congestion even though the peptide itself does not.
Summary
Sh-Polypeptide-93 is a lab-crafted version of insulin-like growth factor binding protein 8 used in cosmetics for one main purpose: skin conditioning. By drawing moisture to the surface and supporting the skin’s own proteins it leaves the complexion soft, smooth and better hydrated, which in turn can reduce the look of fine lines and rough texture.
It is not yet a household name but its gentle profile and vegan sourcing are helping it appear in more serums, light creams and sheet masks every year, especially in products aimed at sensitive or early-aging skin.
Current research and real-world use suggest that Sh-Polypeptide-93 is very safe for topical application with only rare reports of irritation or allergy. As with any new skincare ingredient it is still wise to patch test a fresh product first so you can make sure your skin agrees with it before applying to larger areas.