What Is Sh-Polypeptide-94?
Sh-Polypeptide-94 is a lab-crafted version of a naturally occurring growth factor segment known as IGHD. It is a short chain of amino acids designed to mimic the signaling molecules our skin already uses to stay firm and supple. Most suppliers create it through a controlled fermentation process where genetically guided bacteria or yeast produce the peptide, which is then purified and blended into cosmetic-grade solutions. First explored by biotech researchers studying skin renewal, it found its way into skin care labs in the early 2000s when formulators saw its potential to boost the feel and look of aging skin without heavy oils or fragrances. Today you will spot Sh-Polypeptide-94 in lightweight serums, sheet masks, anti-aging creams, under-eye treatments and concentrated ampoules aimed at smoothing texture and improving overall skin vitality.
Sh-Polypeptide-94’s Cosmetic Benefits/Uses
In topical products Sh-Polypeptide-94 works mainly as a skin-conditioning agent. By supporting the skin’s natural renewal signals it can improve softness, reinforce a healthy moisture barrier and give skin a fresher appearance over time.
Who Can Use Sh-Polypeptide-94
Because it is lightweight and free of occlusive oils Sh-Polypeptide-94 suits normal, dry, oily and combination skin. Its gentle profile also makes it a good option for sensitive skin unless an individual has a specific peptide allergy, which is rare. There are no known drawbacks for darker skin tones or acne-prone complexions as it is non-comedogenic and fragrance free.
The peptide is produced through plant-based or microbial fermentation so finished material contains no animal-derived components. This makes it appropriate for vegans and vegetarians.
Current research has not identified risks specific to pregnancy or breastfeeding when Sh-Polypeptide-94 is applied topically. Still, this is not medical advice and anyone who is pregnant or nursing should discuss new skincare products with a qualified healthcare provider to be extra safe.
Sh-Polypeptide-94 does not increase photosensitivity, so it does not make skin more prone to sunburn. Regular sun protection is always recommended but there is no special SPF requirement tied to this ingredient.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-94 vary from person to person. The points below outline potential side effects that could occur, though most users do not experience them when the ingredient is formulated correctly.
- Mild redness or warmth shortly after application
- Tingling or transient itching as the product absorbs
- Rare allergic contact dermatitis presenting as persistent rash or swelling
- Eye irritation if the formula accidentally migrates into the eyes
If any of these reactions occur discontinue use and consult a healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-94 is a tiny water-soluble peptide that contains no oils, waxes or heavy emollients, so it does not clog pores. It sits on the skin surface or absorbs quickly, then breaks down into amino acids the skin already recognizes. Because of this it is considered non-comedogenic and is suitable for people who are prone to acne or breakouts.
The only caveat is the formula that carries the peptide. If a product pairs Sh-Polypeptide-94 with rich butters or silicone occlusives, those other ingredients—not the peptide itself—could raise the overall pore-clogging risk.
Summary
Sh-Polypeptide-94 is a lab-engineered fragment of a natural growth factor that conditions skin by nudging cell renewal and supporting a smoother moisture barrier. Its light, oil-free nature makes it a versatile addition to serums, gels and eye creams aimed at softening texture and promoting a fresher look.
While not yet a household name, it is gaining steady traction in modern K-beauty and clinical-style formulas thanks to its gentle profile and visible skin-smoothing benefits.
The ingredient is generally regarded as safe for daily topical use with low allergy potential, but as with any new skincare product it is wise to perform a small patch test first to rule out individual sensitivities.