What Is Sh-Polypeptide-98?
Sh-Polypeptide-98 is a lab engineered fragment of angiopoietin-1, a protein naturally found in the body that helps maintain healthy blood vessels and skin tissue. To create it, scientists insert a small section of the angiopoietin-1 gene into harmless host cells such as yeast or bacteria, then let these microbes ferment in controlled tanks. The resulting peptide is purified, dried and blended into cosmetic bases. Interest in bio-identical peptides rose in the early 2000s when brands began searching for gentler options to support the skin’s own repair signals. Since then Sh-Polypeptide-98 has appeared in lightweight serums, anti-aging creams, sheet masks, eye gels and post-procedure soothing treatments because it dissolves easily in water based formulas and remains stable without strong preservatives.
Sh-Polypeptide-98’s Cosmetic Benefits/Uses
Sh-Polypeptide-98 is prized for one key job in skin care.
As a skin conditioning agent it helps the complexion feel softer, smoother and more resilient. By mimicking the calming effect of angiopoietin-1 it can reduce the look of temporary redness, support a healthy moisture barrier and give skin a refreshed, well rested appearance. Routine use may also improve the way other hydrating ingredients spread and absorb, boosting overall product performance.
Who Can Use Sh-Polypeptide-98
Sh-Polypeptide-98 is gentle enough for most skin types including dry, oily, combination, mature and even sensitive skin because it mimics a protein the body already makes. People prone to redness or a fragile moisture barrier often find it soothing. It is not known to clog pores or make oily skin feel heavier.
The peptide is produced through microbial fermentation with no animal-derived material so it is considered suitable for vegans and vegetarians.
No specific warnings have been issued for pregnant or breastfeeding women when Sh-Polypeptide-98 is used in normal cosmetic amounts. Still, this is not medical advice and anyone who is expecting or nursing should show the full product to a healthcare professional before adding it to a routine to be on the safe side.
The ingredient does not make skin more sensitive to sunlight and can be used morning or night. It layers well with most common actives like niacinamide, hyaluronic acid and ceramides and has no known problems when paired with prescription treatments.
Potential Side Effects/Adverse Reactions
Side effects and reactions to topical Sh-Polypeptide-98 can vary from person to person. The issues listed below are only potential outcomes and are not likely to occur for the average user when the ingredient is formulated and used correctly.
- Mild temporary redness or warmth shortly after application
- Itching or tingling in highly sensitive skin
- Rare allergic response such as hives or swelling in those with peptide sensitivities
- Stinging if applied to open cuts or freshly exfoliated areas
If you notice any of these effects stop using the product and seek advice from a qualified healthcare professional.
Comedogenic Rating
Rating: 0 / 5
Sh-Polypeptide-98 is a small, water-soluble peptide that does not leave an occlusive film on the skin. Because it dissolves fully in water-based formulas and contains no heavy oils or waxes it is considered non-comedogenic. This makes it a safe pick for people who struggle with clogged pores or persistent breakouts.
No special factors raise its clogging risk, even in humid weather or under makeup.
Summary
Sh-Polypeptide-98 is a lab-made fragment of angiopoietin-1 that conditions skin, calms the look of temporary redness and helps reinforce the moisture barrier. By acting like a natural signal protein it encourages skin to feel smoother, look more even and stay comfortable through daily stress.
The ingredient pops up mainly in lightweight serums, soothing creams and post-procedure masks, so it is still more of an insider pick than a household name. Brands that focus on barrier care and gentle anti-age formulas are starting to feature it more often as consumers look for kinder alternatives to strong actives.
Overall safety is high. It is non-comedogenic, vegan friendly and does not increase sun sensitivity. Still, every skin is different so it is smart to patch test any new product that lists Sh-Polypeptide-98 before applying it to the whole face.