What Is Sh-Polypeptide-98 Hexapeptide-40?
Sh-Polypeptide-98 Hexapeptide-40 is a lab designed protein made by joining two smaller peptide sequences, sh-Polypeptide-98 and Decapeptide-40, into one longer chain of 485 amino acids. Scientists build the starting gene on a computer then place it inside cultured HeLa cells, which act like tiny factories that ferment the gene and release the finished peptide. The process may add natural tweaks such as disulfide links or sugar groups, giving the ingredient extra stability and skin affinity.
The beauty industry became interested in this fusion peptide when researchers noticed its strong water binding ability and skin friendly profile. As demand for gentle anti-aging and hydration boosters grew, formulators began adding it to products that needed a moisture magnet without the stickiness of heavier ingredients.
Today you will most often spot Sh-Polypeptide-98 Hexapeptide-40 in lightweight serums, sheet masks, leave-on moisturizers, eye creams and specialized treatments aimed at plumping fine lines or soothing dehydrated skin.
Sh-Polypeptide-98 Hexapeptide-40’s Cosmetic Benefits/Uses
In skincare formulas this peptide plays two main roles that translate into visible perks for the user.
- Humectant: It pulls water from the environment and the deeper layers of the skin toward the surface, helping to keep the complexion soft, full and comfortable throughout the day
- Skin Conditioning: By reinforcing the skin’s natural protein network it can leave the surface smoother, improve elasticity and support a healthier looking barrier
Who Can Use Sh-Polypeptide-98 Hexapeptide-40
This moisture-drawing peptide is generally friendly toward all skin types including dry, normal, combination, oily and even sensitive skin because it is lightweight and non greasy. Extremely reactive or allergy-prone individuals should still approach new formulas with caution as with any cosmetic ingredient.
Sh-Polypeptide-98 Hexapeptide-40 is produced using HeLa cells, a human cell line, so it is not considered vegan or vegetarian friendly. Brands may market it as “biotechnology derived,” yet those who avoid animal or human sourced materials will want to steer clear.
No specific data point to risks for pregnant or breastfeeding women when the peptide is applied topically in a finished cosmetic. Still, comprehensive testing during pregnancy has not been done. This information is not medical advice and anyone who is pregnant or nursing should ask a qualified healthcare provider before adding new skin care products.
The ingredient does not make skin more sensitive to sunlight and has no known phototoxic effects. Usual daytime sun protection habits are still encouraged to keep skin healthy. Sh-Polypeptide-98 Hexapeptide-40 plays well with most other actives and does not have reported incompatibilities.
Potential Side Effects/Adverse Reactions
Responses to topical Sh-Polypeptide-98 Hexapeptide-40 differ from person to person. The points below list potential but uncommon reactions. When a product is well formulated most users will not notice any of these issues.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Localized swelling or puffiness
- Contact dermatitis in individuals allergic to peptide structures or fermentation by-products
- Rare acne-like bumps if the overall formula is too rich for the user’s skin
If any of these reactions occur stop using the product and consult a healthcare professional for guidance.
Comedogenic Rating
Rating: 0 out of 5. Sh-Polypeptide-98 Hexapeptide-40 is a large, water-soluble protein that does not sit in pores or add excess oil, so it is not expected to clog follicles or trigger comedones. That makes it a fine choice for people who are prone to acne or breakouts. Because the peptide is typically used at low concentrations and paired with lightweight bases, its presence is unlikely to tip a formula into pore-clogging territory unless other heavy ingredients are involved.
Summary
Sh-Polypeptide-98 Hexapeptide-40 works as both a humectant and a skin-conditioning agent. Its long amino-acid chain latches onto water molecules then holds them at the skin’s surface for lasting hydration while supporting the skin’s protein network for a smoother, more elastic feel. Although not as mainstream as hyaluronic acid or glycerin, the peptide is gaining traction in niche serums and eye treatments looking for a gentle biotech-driven moisture boost. Current data show it is very safe for topical use with only rare reports of mild irritation. As with any new cosmetic ingredient, patch testing is smart practice before applying it over larger areas.