Sodium Butyroyl Hyaluronate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sodium Butyroyl Hyaluronate?

Sodium Butyroyl Hyaluronate is a hybrid molecule created by bonding butyric acid, a short-chain fatty acid, to hyaluronic acid, the well-known moisture magnet naturally present in our skin. Turning this reaction product into its sodium salt form makes it water soluble and easy to blend into creams and serums. The ingredient first appeared in Japanese skincare labs in the early 2010s as scientists searched for a hyaluronic acid derivative that could provide lasting hydration without a sticky feel. Today manufacturers make it through a controlled esterification process: purified hyaluronic acid reacts with food-grade butyric acid, then the mixture is neutralized with sodium hydroxide, filtered and dried into a fine powder.

Because it combines the water-binding talent of hyaluronic acid with the barrier-supporting qualities of butyric acid, formulators add it to lightweight gels, sheet masks, anti-aging lotions, overnight creams and soothing after-sun treatments. It dissolves quickly in water-based phases, plays well with common actives like niacinamide or peptides and does not alter a product’s scent or color.

Sodium Butyroyl Hyaluronate’s Cosmetic Benefits/Uses

This ingredient earns its place on an ingredient list thanks to the roles below:

  • Humectant – pulls water from the environment and deeper skin layers toward the surface giving skin an immediate look of plumpness and reducing the appearance of fine lines
  • Skin conditioning – forms a light flexible film that smooths texture helps reinforce the skin barrier and leaves a soft non-greasy finish

Who Can Use Sodium Butyroyl Hyaluronate

Sodium Butyroyl Hyaluronate is generally well-tolerated by all major skin types. Oily and combination skin appreciate its weightless hydration that does not feel greasy, while dry or mature skin benefits from the extra moisture retention. Sensitive skin usually handles it without trouble because the molecule is non-fragrant and has a low chance of triggering irritation. There are no known reasons for people with eczema, rosacea or acne to avoid it, although each individual may react differently to any new formula.

The ingredient is typically produced through bacterial fermentation of plant-based sugars followed by the addition of butyric acid, so finished material is suitable for vegans and vegetarians. If a brand states it uses bio-fermentation rather than rooster comb–derived hyaluronic acid you can assume it meets plant-based standards.

No specific warnings exist for pregnant or breastfeeding women, but because personal circumstances vary this information is not medical advice. Anyone who is expecting or nursing should run their full skincare lineup past a qualified physician to be extra safe.

Sodium Butyroyl Hyaluronate does not cause photosensitivity and can be used morning or night without increasing sunburn risk. It also works across a broad pH range so it rarely conflicts with other actives.

Potential Side Effects/Adverse Reactions

Responses to topical Sodium Butyroyl Hyaluronate differ from person to person. The points below outline potential side effects, yet most consumers will not experience them when using a properly formulated product.

  • Transient redness or warmth immediately after application
  • Mild stinging on compromised or freshly exfoliated skin
  • Localised irritation due to sensitivity to butyric acid residues
  • Rare allergic contact dermatitis presenting as itching or small bumps
  • Breakouts in acne-prone users if the overall formula is comedogenic

If any discomfort, rash or swelling develops stop using the product and seek guidance from a healthcare professional or dermatologist.

Comedogenic Rating

Rating: 0 / 5

Sodium Butyroyl Hyaluronate is highly water soluble, forms a light breathable film and lacks oily or waxy residues that could block pores, so it earns a zero on the comedogenic scale. The butyric acid portion is chemically bound to the hyaluronic backbone and no free fatty acids remain to act like pore-clogging lipids. This makes the ingredient suitable for skin prone to acne or breakouts.

As always the final product matters: if the formula also contains heavy oils, thick butters or high-silicone levels overall pore-clogging potential can rise even though this single component is non-comedogenic.

Summary

Sodium Butyroyl Hyaluronate works as a humectant and skin-conditioning agent. It attracts water into the upper layers of skin for instant plumping then lays down a flexible moisture-retaining film that supports the barrier and leaves a soft finish. By merging hyaluronic acid’s hydration prowess with butyric acid’s barrier benefits, the molecule delivers lasting moisture without stickiness.

The ingredient is gaining traction in modern gels, masks and serums yet it is still less common than classic sodium hyaluronate so spotting it on an INCI list feels a bit like finding a hidden gem.

Overall safety is high: it is non-comedogenic, fragrance-free and generally well tolerated across skin types. Still, skin can be unpredictable, so patch testing any new product containing Sodium Butyroyl Hyaluronate is a smart habit.

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