Sodium Cottonseedamphoacetate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sodium Cottonseedamphoacetate?

Sodium Cottonseedamphoacetate is an amphoteric surfactant made from fatty acids found in cottonseed oil that are linked to a mild amino-based molecule and then neutralized with sodium. This blend of plant-derived oil and gentle nitrogen-containing chemistry creates a cleanser that can carry both positive and negative charges in water, which helps it work well at different pH levels.

The journey of this ingredient began when manufacturers looked for ways to turn the plentiful by-products of the cotton industry into useful raw materials. By the late 20th century researchers had learned to transform cottonseed fatty acids into stable, skin-friendly surfactants, giving formulators an alternative to harsher soaps.

Production starts with refining cottonseed oil, splitting it into pure fatty acids, then reacting those acids with a compound that contains both amine and carboxylic groups. After controlled steps of condensation, addition of hydroxyethyl groups and neutralization with sodium hydroxide, the finished surfactant appears as a clear to slightly yellow liquid that mixes easily with water.

You will most often see Sodium Cottonseedamphoacetate in gentle facial cleansers, micellar waters, baby shampoos, sensitive skin body washes, foam baths and make-up removers. Its mildness lets brands label products as sulfate-free and non-stripping, which appeals to people who find traditional detergents drying.

Sodium Cottonseedamphoacetate’s Cosmetic Benefits/Uses

In formulas, this ingredient mainly serves one key purpose that delivers several practical benefits.

Cleansing: Sodium Cottonseedamphoacetate lowers the surface tension of water so oils, dirt and make-up can be lifted from skin or hair and rinsed away easily. Because it is amphoteric, it balances charge with other surfactants, boosting foam while keeping irritation low. The result is a cleanser that removes impurities without leaving skin tight or squeaky.

Who Can Use Sodium Cottonseedamphoacetate

This ultra-mild surfactant is generally well tolerated by all skin types including dry, oily, combination and sensitive because it cleans without stripping the skin’s natural moisture barrier. People with a known allergy to cottonseed or related proteins should avoid it, but such sensitivities are rare.

Sodium Cottonseedamphoacetate is made from plant-derived cottonseed oil and common mineral salts so it contains no animal ingredients or by-products. That makes it suitable for both vegetarians and vegans.

The Cosmetic Ingredient Review panel lists this material as safe for use in rinse-off and leave-on products at typical concentrations. Available research shows no specific risks for pregnant or breastfeeding women, but this is not medical advice and anyone who is expecting or nursing should run any skincare product past a qualified health professional just to be on the safe side.

The ingredient does not increase photosensitivity and adds no fragrance of its own so it can be used in daytime or nighttime routines without raising the risk of sun reaction.

Potential Side Effects/Adverse Reactions

Side effects and reactions to topical Sodium Cottonseedamphoacetate can vary from person to person. The points below list potential issues only. When used correctly most people will not notice any negative effects.

Mild skin irritation or redness in very sensitive individuals

Transient stinging if the product gets into the eyes at high concentration

Dryness or tightness if used in an over-cleansing routine

Allergic contact dermatitis in those allergic to cottonseed derivatives

If any unwanted reaction occurs stop using the product and seek medical advice if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 (non-comedogenic)

Sodium Cottonseedamphoacetate is a water-soluble surfactant that rinses off completely and does not leave an oily or waxy film on the skin. Because it lacks the heavy lipids that can settle into pores, it is very unlikely to clog them. Its mild charge-balancing nature also helps keep the skin’s surface clear of residue that could mix with sebum and lead to bumps.

This makes the ingredient suitable for people who are prone to acne or breakouts.

Some formulas pair it with richer emollients. If a product also contains high-level oils or butters, the overall formula, not the surfactant itself, may influence pore-clogging potential.

Summary

Sodium Cottonseedamphoacetate is a gentle plant-derived cleanser that lifts away dirt, oil and makeup while respecting the skin’s natural barrier. Its amphoteric nature lets it work over a wide pH range and play nicely with other surfactants, which keeps foaming stable and irritation low.

Although it is not a buzzworthy headline ingredient, it quietly shows up in many sulfate-free face washes, baby shampoos and sensitive skin products because formulators value its mildness and versatility.

Current safety reviews find it low risk for all skin types at normal use levels. Still, skin can be unpredictable so it is smart to patch test any new product containing this ingredient before adding it to your daily routine.

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