Sodium Polygamma-Glutamate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sodium Polygamma-Glutamate?

Sodium polygamma-glutamate is a salt form of a naturally occurring amino acid chain called polygamma-glutamic acid. This polymer is produced when friendly soil bacteria, most famously Bacillus subtilis, ferment plant proteins such as those in soybeans. If you have ever seen the sticky strings in the traditional Japanese food natto you have already met this ingredient in its culinary form. For cosmetics the fermentation broth is filtered, purified then neutralized with a small amount of sodium to create a water-soluble powder or syrup that blends easily into lotions and gels.

The beauty industry first noticed sodium polygamma-glutamate in the early 2000s while searching for plant-based moisturizers that could rival hyaluronic acid. Its smooth, slippery texture and strong water-binding ability quickly made it a favorite for Asian sheet masks before spreading to global skin and hair care formulas.

Today you will find it in hydrating serums, overnight masks, anti-aging creams, lightweight moisturizers, curl-defining sprays, setting gels and even some refreshing face mists where it helps hold water on the skin surface and improve product feel.

Sodium Polygamma-Glutamate’s Cosmetic Benefits/Uses

Formulators lean on this multitasker for several practical reasons that improve both product performance and user experience.

  • Emulsion stabilising – Keeps oil and water phases from separating so creams stay smooth over time, giving consumers a consistent texture from the first scoop to the last
  • Hair fixing – Forms a flexible film around hair strands that helps hold styles in place without leaving a brittle or flaky finish, making it useful in mousses, gels and sprays aimed at soft control
  • Viscosity controlling – Thickens water-based formulas in a gentle way allowing chemists to fine-tune how fast a serum spreads or how rich a cream feels on the skin

Who Can Use Sodium Polygamma-Glutamate

This ingredient is considered friendly for every major skin type including dry, normal, combination and oily because it hydrates without leaving a heavy or occlusive film. Sensitive complexions usually tolerate it well thanks to its large molecular size which stays on the surface rather than penetrating deeply. There are no known reasons for acne-prone or mature skin to avoid it.

Sodium polygamma-glutamate is sourced through the fermentation of plant proteins and no animal derivatives are needed during manufacturing, making it suitable for vegans and vegetarians.

Current research has not flagged any pregnancy or breastfeeding concerns when the polymer is used in topical cosmetics. This is not medical advice and anyone who is pregnant or nursing should confirm product choices with a doctor to be on the safe side.

The molecule does not increase skin sensitivity to sunlight so there is no added risk of photosensitivity. It is also odorless and has no known interaction issues with common cosmetic actives like vitamin C, niacinamide or retinoids.

Potential Side Effects/Adverse Reactions

Reactions to topical Sodium polygamma-glutamate vary from person to person. The following is a list of potential side effects that remain uncommon when the ingredient is formulated and used correctly

  • Mild redness or itching – can occur if the skin is already compromised or highly reactive
  • Transient stickiness – some users feel a tacky film until the product is fully absorbed
  • Product buildup on hair – possible with leave-in styling products if not shampooed regularly
  • Contact dermatitis – rare allergic reaction that presents as rash or swelling

If you experience any of these effects discontinue use and consult a healthcare professional

Comedogenic Rating

Rating: 0 / 5 – non-comedogenic. Sodium polygamma-glutamate is a large, water-soluble polymer that sits on the skin surface and brings in moisture without blocking pores. It contains no oils or waxy residues that could trap sebum or dead cells, so it earns the lowest possible rating.

Because it does not clog pores it is generally suitable for acne-prone or breakout-prone skin.

The only time buildup could be an issue is if a leave-on hair or face product with a very high level of this polymer is layered repeatedly without cleansing, though this is uncommon.

Summary

Sodium polygamma-glutamate acts mainly as an emulsion stabiliser, a viscosity controller and a flexible film former. Its long, negatively charged chains weave through water phases to keep oil droplets suspended, thicken formulas to the desired feel and leave a light breathable layer that locks in moisture or sets hair styles.

Once a niche ingredient spotlighted in Asian sheet masks it is now appearing in mainstream hydrating serums, moisturisers and gentle styling gels, yet it still has plenty of room to grow compared with household names like hyaluronic acid.

Current data show it is low risk, non-comedogenic and well tolerated across skin types. As with any new cosmetic, do a small patch test first to confirm personal compatibility.

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