What Is Sr-Hagfish Polypeptide-1?
Sr-Hagfish Polypeptide-1 is a lab crafted version of a protein fragment first discovered in the slime threads of the Pacific hagfish, an eel-like fish known for producing remarkably strong yet silky fibers when threatened. Chemically, it is a short chain of amino acids that forms part of the thread biopolymer filament subunit alpha. Scientists were intrigued by the thread’s ability to trap water and form a flexible shield, qualities that line up nicely with what skin often needs. Early marine-biology studies on hagfish slime sparked interest in the textile field, but cosmetic chemists soon realized the same protein traits could help care for skin. Today the ingredient is produced through fermentation: the gene that codes for the polypeptide is inserted into harmless yeast or bacteria, which grow in stainless-steel tanks and secrete the protein. After purification and drying, the powder is ready to blend into formulas. You will most often see Sr-Hagfish Polypeptide-1 in lightweight serums, hydrating sheet masks, anti aging creams, overnight repair treatments, soothing gels and protective hand or body lotions.
Sr-Hagfish Polypeptide-1’s Cosmetic Benefits/Uses
Formulators reach for this marine inspired peptide because it serves several useful roles in one shot:
- Humectant – pulls moisture from the air and holds it at the skin’s surface, leaving skin looking plumper and feeling softer
- Skin conditioning – smooths rough texture, supports suppleness and helps reduce the appearance of fine lines by reinforcing the skin’s protein network
- Skin protecting – forms a light breathable film that shields against dryness and everyday environmental stress, helping maintain a healthy barrier
Who Can Use Sr-Hagfish Polypeptide-1
Thanks to its lightweight water-binding nature Sr-Hagfish Polypeptide-1 is well tolerated by most skin types. Dry or mature skin often sees the biggest boost in softness and elasticity while oily and combination skin appreciate the non-greasy feel. Sensitive skin typically handles the ingredient well as it forms a calming moisture film, though anyone with a known peptide allergy or a history of reacting to fermented ingredients should proceed carefully.
The material is produced in fermentation tanks using microbes, not harvested from fish, so it meets vegan and vegetarian standards. Finished formulas may still include non-vegan additives, so label readers should check the entire ingredient list.
No data suggest the peptide poses a specific risk for pregnant or breastfeeding women when used topically in normal cosmetic concentrations. That said this is not medical advice and anyone who is expecting or nursing should run their full skincare routine past a qualified healthcare professional before use.
The ingredient does not absorb UV light and is not known to make skin more sensitive to the sun. Standard daily sunscreen is still encouraged for overall skin health.
Potential Side Effects/Adverse Reactions
Reactions to topical Sr-Hagfish Polypeptide-1 differ from person to person. The effects listed below are only potential issues and are unlikely for the average user when the product is properly formulated.
- Mild redness or warmth
- Tingling or stinging on very compromised skin
- Allergic contact dermatitis in individuals sensitized to specific amino acid sequences or fermentation residues
- Temporary breakouts if the formula also contains heavy oils that clog pores
If any irritation or other unwanted reaction occurs stop using the product and seek advice from a healthcare professional.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Sr-Hagfish Polypeptide-1 is a small, water-soluble peptide that does not contain heavy oils, waxes or fatty acids typically linked to pore blockage. It sits lightly on the skin as a thin moisture film and is rinsed away easily with routine cleansing, so it has virtually no tendency to trap sebum or debris inside pores. This makes it generally suitable for people prone to acne or breakouts. Keep in mind the overall formula still matters since comedogenicity can rise if the peptide is paired with occlusive ingredients like certain butters or thick silicones.
Summary
Sr-Hagfish Polypeptide-1 works as a multitasking humectant, skin conditioning and skin protecting agent. It attracts and holds water for lasting hydration, helps smooth texture by supporting the skin’s own protein network and forms a breathable shield that guards against environmental stress. While its marine inspiration sparks interest, the material is still a niche pick due to limited supply and higher production costs, so you will mostly find it in select premium serums and masks rather than everyday drugstore lines.
Safety data so far show a low risk of irritation or allergy for most users when the peptide is used at typical cosmetic levels. As with any new skincare ingredient it is smart to patch test a fresh product first to confirm personal compatibility.