Sr-Ocean Pout Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Ocean Pout Polypeptide-1?

Sr-Ocean Pout Polypeptide-1 is a lab refined version of an antifreeze protein originally identified in the blood of the ocean pout, a cold-water fish that thrives in near-freezing North Atlantic seas. Chemically, it belongs to the Type III antifreeze protein family and is often labeled as QAL (HPLC 12) to indicate its purity profile. In skin care the peptide is valued for the way its unique structure binds water molecules and stabilizes cell membranes under stress.

The journey from fish to face cream began in the late 1990s when researchers studying marine life noticed that these proteins could protect living tissues from dehydration damage. Cosmetic chemists later adapted biotech fermentation techniques to produce the peptide without harvesting fish. Today genetically engineered yeast or plant cell cultures secrete the protein, which is then isolated, purified by high-performance liquid chromatography, and standardized for cosmetic use.

Because of its protective, hydrating character Sr-Ocean Pout Polypeptide-1 shows up in moisturizers, sheet masks, overnight creams, anti-aging serums, soothing after-sun gels, and any formula aimed at boosting skin resilience in harsh climates or during seasonal changes.

Sr-Ocean Pout Polypeptide-1’s Cosmetic Benefits/Uses

In topical products this marine peptide serves one clear purpose that delivers multiple payoffs for the skin.

Skin conditioning: Sr-Ocean Pout Polypeptide-1 helps skin hold on to water, smoothes rough texture, and supports a healthier barrier. By mimicking the fish’s natural defense against cold-induced dehydration it keeps the stratum corneum supple, reduces the look of fine dry lines, and leaves skin feeling soft and refreshed.

Who Can Use Sr-Ocean Pout Polypeptide-1

Sr-Ocean Pout Polypeptide-1 is generally suitable for all skin types including dry, normal, combination, oily and sensitive skin because it adds lightweight hydration without leaving a greasy film. Users prone to breakouts also tend to tolerate it well since the peptide itself is non occlusive.

The ingredient is produced in biotech fermenters rather than harvested from fish so finished material is free of animal by-products. This makes it appropriate for vegetarians and vegans who look for cruelty free options.

Current data shows no specific risks for pregnant or breastfeeding users when the peptide is applied topically in cosmetic amounts. This is not medical advice and anyone who is pregnant or nursing should confirm product choices with a health professional to be on the safe side.

Sr-Ocean Pout Polypeptide-1 does not make skin more sensitive to sunlight so it can be used morning or night without changing your normal sunscreen habits.

Potential Side Effects/Adverse Reactions

Individual reactions to topical Sr-Ocean Pout Polypeptide-1 vary. The points below outline potential effects though most people experience none of them when the ingredient is formulated and used correctly.

  • Mild redness or warmth in very sensitive skin during the first few uses
  • Itching or transient stinging if applied to compromised or freshly exfoliated skin
  • Localized irritation from interaction with a harsh preservative or high alcohol content in the overall formula rather than the peptide itself
  • Allergic contact dermatitis in rare cases for those with a known protein allergy

If any discomfort or visible reaction develops stop using the product and consult a qualified skincare professional or physician

Comedogenic Rating

Rating: 0 / 5

Sr-Ocean Pout Polypeptide-1 is a small, water soluble protein that does not form an oily film or clog pores so it earns a zero on the comedogenic scale. Its molecular structure disperses easily in water based systems and it is usually added at low concentrations, both of which keep pore blockage risk minimal.

This makes the ingredient suitable for skin that is prone to acne or breakouts.

Only the full formula can change the pore clogging potential; if the product also contains heavy butters or waxes that rating will reflect the other ingredients rather than the peptide itself.

Summary

Sr-Ocean Pout Polypeptide-1 is a biotech marine peptide prized for skin conditioning. It binds water to the outer skin layers, smooths rough spots and helps reinforce the natural barrier, which in turn reduces dryness lines and improves comfort. The ingredient is still more of a niche addition than a mass market staple but it is slowly gaining traction in moisturizers, serums and masks aimed at users who want an extra layer of environmental protection.

Safety data show a low risk profile with only rare irritation reports, making it broadly safe for daily use. As with any new skincare product it is wise to do a small patch test before full application to make sure your skin agrees with the complete formulation.

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