What Is Sr-Oligopeptide-150 Silkworm Polypeptide-2 Dipeptide-19 Hexapeptide-40?
Sr-Oligopeptide-150 Silkworm Polypeptide-2 Dipeptide-19 Hexapeptide-40 is a lab made peptide that comes from recombinant technology. Scientists piece together genetic code from four smaller peptides then insert that code into a safe strain of E. coli. During fermentation the bacteria use the code to build a single chain protein made of 757 amino acids, which may form natural disulfide bridges or hold simple sugar groups. After the protein is grown it is filtered, purified and carefully trimmed to meet cosmetic grade standards.
The idea of blending silkworm and designer peptides grew out of research on silk’s natural ability to help skin retain moisture. By combining segments known for soothing and conditioning effects chemists created a more powerful multitasking peptide. It entered cosmetic labs in the late 2010s when advances in fermentation made large scale production affordable and consistent.
Today you will mostly find this ingredient in leave-on products where close contact with skin lets it work best. Common formats include lightweight serums, anti-aging creams, overnight masks, eye treatments and premium sheet masks. It can also appear in post-peel or post-laser calming gels given its gentle conditioning nature.
Sr-Oligopeptide-150 Silkworm Polypeptide-2 Dipeptide-19 Hexapeptide-40’s Cosmetic Benefits/Uses
The main role of this peptide in skin care is straightforward yet valuable. It serves as a skin conditioning agent, meaning it helps the surface feel softer, smoother and better hydrated. By forming a thin flexible film it can reduce moisture loss, support the skin barrier and give a quick silky after-feel that many users appreciate.
Who Can Use Sr-Oligopeptide-150 Silkworm Polypeptide-2 Dipeptide-19 Hexapeptide-40
This peptide is generally well tolerated by all major skin types including oily, dry, normal and combination skin. Its feather light film helps lock in water without clogging pores so even acne-prone users usually do well. Sensitive skin also tends to accept it because it has no fragrance or strong acids that could sting.
The ingredient is produced through microbial fermentation with no animal harvesting so it is considered suitable for both vegetarians and vegans. The word “silkworm” refers to the genetic code used to design the peptide, not to an actual silk extract taken from insects.
No specific warnings exist for pregnancy or breastfeeding, but data on this exact peptide are limited. This content is not medical advice and anyone who is pregnant or nursing should show the full product label to a healthcare professional before using it.
The peptide does not absorb light in a way that would make skin more sensitive to the sun, so it is not known to cause photosensitivity. Standard daily sunscreen use is still recommended for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Sr-Oligopeptide-150 Silkworm Polypeptide-2 Dipeptide-19 Hexapeptide-40 can differ from person to person. The issues listed below are possible but uncommon when the ingredient is included at normal cosmetic levels and produced to proper quality standards.
- Mild redness or warmth some users with very reactive skin may notice temporary flushing when the product is first applied
- Itching rare histamine-type itch can occur in highly sensitive individuals
- Contact dermatitis an allergic response is unlikely yet possible with any protein based ingredient
- Eye irritation if the formula accidentally gets into the eyes it may cause watering or stinging until rinsed out
If you experience any persistent irritation or discomfort stop using the product and consult a healthcare professional.
Comedogenic Rating
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This peptide is a large, water-soluble molecule that sits on the surface of skin rather than penetrating and mixing with sebum. It does not contain heavy oils, waxes or fatty acids that typically clog pores. Most finished formulas using it are lightweight serums or gels, which further lowers the chance of congestion.
Suitable for acne-prone and breakout-prone skin.
Its lab-grown nature also means there is no variability in composition that could create pore-blocking residues from batch to batch.
Summary
Sr-Oligopeptide-150 Silkworm Polypeptide-2 Dipeptide-19 Hexapeptide-40 is a lab crafted skin-conditioning peptide that forms a breathable film on the surface, helping skin hold moisture, feel smoother and look calmer. It is still a niche ingredient reserved for higher-end formulas because fermentation and purification costs keep it out of mass products, yet those who have tried it often report a pleasant silky finish.
Current safety data and user feedback point to a very low risk of irritation with no comedogenicity, photosensitivity or animal-origin concerns. As with any new skincare ingredient it is wise to patch test a small area first to confirm personal tolerance before applying broadly.