Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2?

Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2 is a lab-designed fusion peptide inspired by two naturally occurring protein fragments found in rainbow trout. Scientists joined the genes for each peptide then placed the fused gene into harmless strains of E. coli. During fermentation the bacteria act like tiny factories, churning out an 84-amino-acid chain that can feature stabilizing disulfide bonds and sugar groups. After the culture phase the peptide is purified, filtered and dried into a fine powder that blends easily with water-based cosmetic bases.

Peptides first attracted attention in skin care during the early 2000s when researchers showed they could signal repair and protect against stress. This particular fusion was developed to combine two sets of benefits in one stable molecule, letting formulators achieve more with fewer raw materials. You will most often spot it in anti-aging serums, sheet masks, lightweight moisturizers, targeted eye treatments and leave-in or rinse-off hair products that aim to fight free-radical damage while supporting a healthy scalp.

Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2’s Cosmetic Benefits/Uses

This multifunction peptide gives formulators three key performance areas

  • Antioxidant – helps neutralize free radicals created by UV light and pollution, which can otherwise speed up visible aging and dullness
  • Hair conditioning – forms a thin film over strands to smooth cuticles, reduce frizz and boost softness without heavy buildup
  • Skin protecting – supports the skin barrier by reinforcing surface proteins and limiting moisture loss, keeping skin feeling comfortable and resilient

Who Can Use Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2

This lab made peptide is generally well tolerated across normal, dry, oily, combination and sensitive skin since it is lightweight and free of added fragrance or common sensitizers. Its film forming nature can even help temper irritation on reactive complexions. Those with very oily or acne prone skin usually handle it fine too because it does not clog pores or leave a greasy residue.

Although the source inspiration is rainbow trout the commercial ingredient is made entirely through yeast free bacterial fermentation without any animal tissue. No fish proteins remain, making finished products suitable for vegans and vegetarians.

No data show hormonal or systemic activity so pregnant or breastfeeding women can typically use products containing the peptide. This is not medical advice and anyone who is pregnant or nursing should review new skin or hair care products with a qualified health professional first.

The peptide does not increase photosensitivity so you can apply it morning or night. Of course daily sunscreen is still wise when spending time outdoors. The ingredient plays well with most other actives and does not affect the color or scent profile of a formula, which is why it appears across a wide range of leave-on and rinse-off products.

Potential Side Effects/Adverse Reactions

Individual responses to topical Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2 can differ. The following points are potential, not expected, especially when a reputable brand has formulated the product correctly.

  • Mild redness or warmth at the application site
  • Transient stinging or tingling, particularly on very dry or compromised skin
  • Allergic contact dermatitis in those sensitive to certain peptides or fermentation residues
  • Watery eyes or slight itching if the peptide is used in a spray or mist that drifts into the eye area
  • Scalp buildup or limp hair when overused in leave-in conditioners, more noticeable on fine hair

If any of these reactions occur stop using the product and consult a medical professional if symptoms persist or worsen.

Comedogenic Rating

Rating: 0 / 5. Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2 is a water-soluble peptide without fatty acids, waxes or heavy silicones so it does not clog pores or sit occlusively on the skin. It rinses clean in shampoos and remains weightless in leave-on formulas which keeps follicle blockage unlikely.

That makes the ingredient suitable for acne-prone or breakout-prone skin types.

Keep in mind the finished product’s overall recipe matters; if the formula pairs the peptide with rich butters or oils the final comedogenic potential could rise.

Summary

Sr-Rainbow Trout Oligopeptide-1 Sh-Oligopeptide-2 acts as an antioxidant, a barrier-supportive skin protector and a light hair-conditioning agent. Its 84-amino-acid chain can bind surface proteins, mop up free radicals created by UV and pollution and lay down a breathable film that smooths cuticles while reducing water loss.

The peptide is still a niche active found mostly in higher-end serums, masks and specialty hair treatments, but its multitasking profile is earning steady interest from indie formulators and large brands looking to streamline ingredient lists.

Current safety data and post-market experience point to a low risk of irritation or systemic effects when used topically. As with any new product though it is wise to do a quick patch test to make sure your skin or scalp agrees with the full formula.

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