Sr-Rice Polypeptide-1: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Sr-Rice Polypeptide-1?

Sr-Rice Polypeptide-1 is a short chain of amino acids inspired by OsHsp16.9A, a small heat shock protein found in rice. Scientists noticed that rice plants rely on this protein to cope with stress such as heat and UV light, then explored how a lab made version could protect skin and hair in a similar way. Today the peptide is produced through controlled fermentation or solid phase synthesis, giving a pure, stable ingredient that is easy to add to cosmetic formulas. You will spot it in lightweight serums, hydrating gels, soothing sheet masks, leave-in hair conditioners, anti-aging creams and after-sun products where gentle protection and moisture balance are key.

Sr-Rice Polypeptide-1’s Cosmetic Benefits/Uses

Formulators choose Sr-Rice Polypeptide-1 for a mix of protective and beautifying perks

  • Antimicrobial: Helps keep the product itself free from unwanted microbes and supports a clearer looking complexion by discouraging surface bacteria
  • Antioxidant: Neutralizes free radicals from pollution or UV exposure, which can otherwise lead to dullness and early signs of aging
  • Hair Conditioning: Smooths the cuticle, boosts softness and adds a light protective film that can reduce breakage
  • Humectant: Attracts water to the skin and hair shaft, improving hydration without a heavy feel
  • Skin Conditioning: Leaves skin feeling supple, calmer and more resilient thanks to its soothing nature
  • Skin Protecting: Forms a breathable shield that helps defend against environmental stress like wind or urban grime

Who Can Use Sr-Rice Polypeptide-1

This peptide is generally well tolerated by all skin types including dry, oily, combination and sensitive skin because it is lightweight and non occlusive. Those with very reactive or allergy-prone skin may prefer formulas with minimal added fragrance to reduce the chance of irritation, but the peptide itself is considered gentle.

Sr-Rice Polypeptide-1 is produced through fermentation or synthetic peptide technology with no animal-derived steps, so products containing it are suitable for vegetarians and vegans.

Pregnant or breastfeeding individuals are not known to face specific risks from topical Sr-Rice Polypeptide-1. Still this is not medical advice and anyone expecting or nursing should review all skincare products with a qualified healthcare provider to be safe.

The ingredient does not cause photosensitivity and can be applied morning or night. It pairs well with sunscreen and common actives like niacinamide or hyaluronic acid. No special restrictions apply when using it alongside retinoids or acids, though layering order and overall formula strength should always be considered for comfort.

Potential Side Effects/Adverse Reactions

Reactions to topical Sr-Rice Polypeptide-1 can vary from person to person. The points below outline potential side effects yet most users will not experience them when the ingredient is formulated and used correctly.

  • Mild redness or transient tingling in very sensitive skin
  • Allergic contact dermatitis in individuals with a specific rice protein allergy
  • Temporary stinging if applied to broken or freshly exfoliated skin
  • Formula-related breakout if combined with heavy occlusives in acne-prone users

If you experience ongoing irritation discomfort or any unexpected reaction discontinue use and seek guidance from a healthcare professional

Comedogenic Rating

Rating: 0 / 5

Sr-Rice Polypeptide-1 is a tiny, water-soluble peptide that does not leave an oily film or block pores. It acts more like a lightweight humectant than an emollient so it earns the lowest possible comedogenic score. This makes the ingredient suitable for people who are prone to acne or frequent breakouts. As always the overall formula still matters; heavy butters, waxes or silicones paired with the peptide could raise a product’s pore-clogging potential.

Summary

Sr-Rice Polypeptide-1 is a lab crafted version of a rice heat shock protein that offers antimicrobial support, antioxidant defense, humectant hydration, skin and hair conditioning and a light protective shield. It delivers these benefits by binding water, neutralizing free radicals and forming a gentle film that calms and fortifies the skin barrier while smoothing hair cuticles.

The peptide is gaining steady attention in newer serums, masks and leave-in conditioners but it is not yet as ubiquitous as classics like hyaluronic acid or niacinamide. Early adopters appreciate its multitasking nature and plant-derived story so its presence is expected to grow.

Safety data and real-world use show Sr-Rice Polypeptide-1 to be low risk for irritation in most skin types including sensitive and acne prone. Still it is wise to patch test any new product to rule out personal sensitivities before full-face or scalp application.

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