What Is Tetrapeptide-31?
Tetrapeptide-31 is a lab made mini protein built from four units of the simple amino acid glycine. Because the chain is created in a controlled setting, it is free from animal or plant impurities and remains consistent from batch to batch. Peptides started gaining attention in skincare in the early 2000s for their ability to signal and support skin functions, and Tetrapeptide-31 joined the lineup a few years later when formulators were looking for gentle options that could stand up to daily use. It is produced through solid-phase peptide synthesis, a step-by-step method where each glycine is added in sequence, then the finished chain is purified, dried and usually blended into a water-glycerin solution before being shipped to brands. You will most often spot it in lightweight serums, eye creams, firming concentrates, sheet masks and other leave-on anti-aging treatments that aim to smooth and refresh the look of skin.
Tetrapeptide-31’s Cosmetic Benefits/Uses
When included in a formula Tetrapeptide-31 mainly serves one purpose that can still have a noticeable payoff for the skin.
Skin conditioning: this peptide helps the surface of the skin feel softer and look more even. With continued use it can support a fresher appearance, offset rough texture and leave the complexion looking well cared for.
Who Can Use Tetrapeptide-31
Tetrapeptide-31 is mild enough for most skin types, including dry, normal, combination and oily skin, because it focuses on surface conditioning without heavy oils or strong actives. People with sensitive or reactive skin usually tolerate it well thanks to its minimalist structure, but if sensitivity is triggered by any peptide or preservative in the finished product it could still cause redness or itching. The peptide itself is fully synthetic and contains no animal derivatives, so it is suitable for vegans and vegetarians.
Pregnant or breastfeeding individuals are not known to face specific risks from the topical use of Tetrapeptide-31, yet regulations for cosmetic ingredients during pregnancy are limited. This is not medical advice and anyone who is pregnant or nursing should review any skincare product with a medical professional before adding it to a routine.
The ingredient does not increase photosensitivity, so there is no special daylight restriction beyond the usual recommendation of daily sunscreen for overall skin health.
Potential Side Effects/Adverse Reactions
Responses to topical Tetrapeptide-31 differ from person to person. Below is a list of potential side effects that can occur even though they are unlikely when the ingredient is formulated and used correctly.
- Mild stinging or warmth brief skin sensation as the product absorbs
- Temporary redness localized flush that subsides after application
- Itchiness possible in people already prone to peptide sensitivity
- Contact dermatitis rare but possible allergic reaction presenting as rash or swelling
If any of these effects appear and do not quickly calm, stop using the product and seek guidance from a healthcare professional.
Comedogenic Rating
Rating: 0/5. Tetrapeptide-31 is a tiny water-soluble peptide with no oily or waxy backbone so it does not block pores. Because it dissolves completely in the watery phase of a formula it rinses or absorbs without leaving a residue that could trap sebum or debris. This makes it suitable for people who are prone to acne or breakouts. As always the finished product’s entire ingredient list determines real-world pore-clogging potential so check for heavy oils or butters elsewhere in the formula.
Summary
Tetrapeptide-31 is a lab-crafted chain of four glycine units that works as a skin-conditioning agent, helping the surface feel softer and look smoother. By supporting a more even texture it refreshes dull or rough areas and pairs well with moisturizers and gentle actives.
It is not the most famous peptide on the market but it shows up in targeted serums, eye creams and sheet masks aimed at maintaining a well-cared-for complexion. Its low irritation profile and non-comedogenic nature make it a safe pick for most skin types including sensitive and acne-prone users.
Overall safety data flags very few concerns. Still, everyone’s skin is unique so perform a small patch test when trying any new product containing Tetrapeptide-31 to confirm personal tolerance.