What Is Tetrapeptide-62 Norleucyl Oligopeptide-149?
Tetrapeptide-62 Norleucyl Oligopeptide-149 is a lab made chain of 55 amino acids built from smaller pieces called Tetrapeptide-62 and norleucine. Because it is synthetic scientists can fine-tune its purity and stability which is one of the reasons cosmetic chemists favor it over natural extracts that can vary from batch to batch.
The journey of this peptide into skincare began when researchers looked for gentler ways to defend skin from early signs of aging triggered by everyday stress like pollution or UV exposure. Peptides were already popular for firming and signaling benefits so adding antioxidant activity in a single complex made this ingredient attractive to formulators. After safety testing it started appearing in premium creams around the late 2010s then gradually moved into mid-priced products as production costs dropped.
Manufacturing involves solid-phase peptide synthesis where each amino acid is added in a carefully controlled order on a resin support. After all 55 units are linked the chain is cut from the resin purified and blended into a water-based solution ready for skincare labs. This process makes sure the final ingredient is consistent and free from unwanted residues.
You will most often find Tetrapeptide-62 Norleucyl Oligopeptide-149 in lightweight serums anti-aging moisturizers sheet masks and eye creams. Brands include it when they want to boost the overall antioxidant capacity of a formula without adding heavy oils or strong fragrances.
Tetrapeptide-62 Norleucyl Oligopeptide-149’s Cosmetic Benefits/Uses
In skincare this peptide complex mainly shines as an antioxidant that helps the formula guard the skin from daily environmental stress.
As an antioxidant Tetrapeptide-62 Norleucyl Oligopeptide-149 can neutralize free radicals before they start damaging proteins and lipids in the skin. By easing this invisible stress it supports a smoother brighter look and pairs well with other age defending ingredients like vitamins C and E. This protective role also helps maintain the freshness of the product itself which can extend shelf life and keep textures stable.
Who Can Use Tetrapeptide-62 Norleucyl Oligopeptide-149
This antioxidant peptide is considered gentle enough for all skin types, including sensitive, oily, dry and combination. Because it is water-based and free of heavy oils it will not clog pores, so acne-prone users can usually enjoy it without extra breakouts. There are no known reasons it would be unsuitable for mature or younger skin, though benefits are most noticeable for those looking to defend against early aging signs.
The ingredient is made entirely by synthetic peptide synthesis with no animal-derived raw materials, so it fits vegan and vegetarian lifestyles.
Current data does not show specific risks for women who are pregnant or breastfeeding, yet clinical research in these groups is limited. This information is not medical advice; anyone expecting or nursing should check with a healthcare professional before adding new skincare products.
Tetrapeptide-62 Norleucyl Oligopeptide-149 does not make skin more sensitive to sunlight. Regular sunscreen use is still important for overall skin health when using any antioxidant product.
Potential Side Effects/Adverse Reactions
Responses to topical Tetrapeptide-62 Norleucyl Oligopeptide-149 can vary from person to person. The points below list potential side effects, yet most users will not run into these issues when the ingredient is used at proper cosmetic levels.
- Mild redness or warmth at the application site
- Temporary itching or tingling
- Dryness if the overall formula lacks moisturizing agents
- Allergic contact dermatitis in individuals sensitive to peptides or other formula components
- Interaction with strong exfoliating acids that could heighten irritation for very sensitive skin
If you notice any of these reactions stop using the product and consult a healthcare professional or dermatologist for guidance.
Comedogenic Rating
Rating: 0 (non-comedogenic)
Tetrapeptide-62 Norleucyl Oligopeptide-149 is a large water-soluble molecule with no oily or waxy backbone, so it does not block pores or leave a film that traps sebum. Formulas that feature it are usually lightweight serums or gels, further reducing any pore-clogging risk. For these reasons it is considered safe for acne-prone or breakout-prone skin. If breakouts do occur they are more likely linked to other ingredients in the product rather than the peptide itself.
Summary
Tetrapeptide-62 Norleucyl Oligopeptide-149 works mainly as an antioxidant, scavenging free radicals before they can weaken collagen or dull the skin. Its lab-built 55-amino-acid chain lets it stay stable in water-based formulas and play well with classic antioxidants like vitamins C and E. The ingredient is still a niche entry in the peptide family, showing up mostly in mid to high-end anti-aging serums and eye creams, yet its clean safety profile and versatility mean you will likely see it gain ground as peptide tech becomes more affordable.
Current research shows low irritation potential, no phototoxicity and no comedogenicity, so most users can apply it without concern. As with any new skincare ingredient, a simple patch test on a small area of skin is a smart move to rule out personal sensitivity before full-face use.