Thymol Trimethoxycinnamate: What Is It, Cosmetic Uses, Benefits & Side Effects

Curious about this ingredient? In this article we're explaining exactly what it is and why it's used within cosmetic formulations.
Updated on: June 30, 2025
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We verify all information on this page using publicly available nomenclature standards from The Personal Care Products Council (PCPC), the European Commission's CosIng database and documentation provided directly by ingredient manufacturers. Our analysis is based on technical data from these sources to ensure accuracy and reliability.

What Is Thymol Trimethoxycinnamate?

Thymol Trimethoxycinnamate is a lab-crafted ester that combines thymol, the fragrant compound found in thyme, with trimethoxycinnamic acid, a cousin of the natural antioxidant cinnamic acid. Chemists developed it in the early 2000s while looking for stable, plant-inspired molecules that could guard skin against daily stress. The ingredient is made through an esterification process: thymol is reacted with trimethoxycinnamic acid under controlled heat, then purified to remove any leftover reactants so only the active ester remains.

Because it offers antioxidant and skin-protective qualities without the strong scent of raw thyme, formulators soon started adding it to leave-on skincare in place of harsher synthetic stabilizers. Today you will most often spot Thymol Trimethoxycinnamate in lightweight day creams, anti-aging serums, protective primers, after-sun lotions and sheet masks aimed at dull or stressed skin. Its oil-compatible structure lets it blend easily into both water-in-oil and oil-in-water emulsions, making it a flexible choice for many textures.

Thymol Trimethoxycinnamate’s Cosmetic Benefits/Uses

In skincare formulas Thymol Trimethoxycinnamate plays two key roles that help keep skin looking healthy.

  • Antioxidant: It scavenges free radicals formed by UV light and pollution which helps slow the look of premature aging and supports a more even skin tone
  • Skin protecting: By reinforcing the skin’s surface lipids it limits moisture loss and shields against environmental irritants so skin feels calmer and better hydrated

Who Can Use Thymol Trimethoxycinnamate

Thanks to its light, oil-compatible structure Thymol Trimethoxycinnamate suits most skin types including normal, dry, combination, oily and sensitive. It is considered non-comedogenic so it will not clog pores, and its calming edge often makes it welcome in redness-prone routines. People who are allergic to thyme or other Lamiaceae herbs should proceed carefully because the thymol part of the molecule could still trigger cross-reactivity.

The ingredient is synthesized in a lab without animal-derived raw materials which makes it suitable for vegans and vegetarians. Manufacturers typically use plant-based solvents and cruelty-free processes as well, though it is wise to check brand policies if that matters to you.

No data point to hormonal activity, so products with Thymol Trimethoxycinnamate are generally viewed as safe for pregnant or breastfeeding women. This is not medical advice and anyone who is expecting or nursing should have a quick chat with their doctor before adding new skincare just to be safe.

Thymol Trimethoxycinnamate does not cause photosensitivity and can even lend a bit of extra antioxidant back-up under sunscreen. Standard sun protection is still needed because it is not a UV filter. The ingredient also plays nicely with common actives like niacinamide and peptides which makes layering easy.

Potential Side Effects/Adverse Reactions

  • Mild stinging or warmth
  • Temporary redness
  • Dry patches in very dehydrated skin
  • Contact dermatitis in individuals sensitive to thyme or related botanicals
  • Rare allergic rash or hives

If any of these reactions appear stop using the product and seek advice from a healthcare professional.

Comedogenic Rating

Rating: 0–1 (very low)

Thymol Trimethoxycinnamate is a small, lightweight ester that absorbs without forming a heavy film on the skin. It sits in the oil phase of a formula yet does not have the thick or waxy structure associated with pore blockage. Current patch tests on acne-prone panels show little to no increase in comedone count, supporting the 0–1 score.

Given this low rating the ingredient is generally considered suitable for people who are prone to breakouts. Its antioxidant role may even help calm the look of inflammation that often accompanies acne.

As with any ingredient, the overall comedogenicity of a finished product depends on the full ingredient list and texture so always look at the full formulation if clogging is a concern.

Summary

Thymol Trimethoxycinnamate is an antioxidant and skin protecting ester inspired by thyme and cinnamic acid. It neutralises free radicals from UV light and pollution and reinforces surface lipids to reduce moisture loss which keeps skin looking smooth and resilient.

The molecule is still something of a niche act compared with big names like vitamin C yet formulators appreciate its stability, mildness and versatility so it is popping up in more modern day creams serums and masks.

Current data show it is low risk for irritation or pore clogging when used at cosmetic levels. Nevertheless skin is individual so it is smart to patch test any new product that contains Thymol Trimethoxycinnamate to ensure personal compatibility.

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